On the role of biogenic amines and reactive oxygen species in the disruption of the hypothalamic regulation of reproductive function in xenobiotic-induced and experimental hyperhomocysteinemia

Resumo

This review describes the role of biogenic amines in the hypothalamic regulation of ovarian cycles in female rats. The mechanisms of action of industrial xenobiotics and experimental hyperhomocysteinemia, which induces premature aging of the reproductive function, are discussed. The point of view that the damaging action of reactive oxygen species is the basis of the unified response of hypothalamic regulation of reproductive cycles to external and internal neurotoxic impacts is substantiated. We describe the involvement of melatonin and short regulatory peptides in antioxidant protection of the reproductive system during aging.