The Influence of Noopept on Morphological, Electrophysiological, and Biochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels


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Аннотация

We studied the influence of the neuroprotective dipeptide drug noopept on the state of the retina during thrombosis of its vessels in an experiment with male chinchilla rabbits. The pathology was modeled by intravenous injection of rose Bengal at a dose of 40 mg/kg followed by transpupillary focal illumination with white light of the temporal vascular arcade for 10 min. Noopept was administered intravenously immediately after modeling thrombosis at a dose of 0.5 mg/kg, and then three times per day per os at a dose of 10 mg/kg throughout the experiment. It was found that noopept improves the functional state of the retinal neurons according to electroretinography. At the 5–7th and 14th days, noopept reduced the glutamate content in the retina by 86.8% and 84.1% compared to the control animals (p < 0.05), decreased the concentration of products of reaction with thiobarbituric acid by 17.3% and 14.9% on the 3rd and 7th days (p < 0.05), and increased the activity of glutathione-S-transferase by 34.5% on the 1st day (p < 0.05).

Авторлар туралы

A. Kolesnikov

Ryazan State Medical University

Email: alekseyshulkin@rambler.ru
Ресей, Ryazan

A. Shchul’kin

Ryazan State Medical University; Aff5

Хат алмасуға жауапты Автор.
Email: alekseyshulkin@rambler.ru
Ресей, Ryazan; ul. Vysokovol’tnaya 9, Ryazan, 390026

M. Pisklova

Zakusov Institute of Pharmacology

Email: alekseyshulkin@rambler.ru
Ресей, Moscow

O. Barenina

Ryazan State Medical University

Email: alekseyshulkin@rambler.ru
Ресей, Ryazan

E. Yakusheva

Ryazan State Medical University

Email: alekseyshulkin@rambler.ru
Ресей, Ryazan

V. Kudrin

Zakusov Institute of Pharmacology

Email: alekseyshulkin@rambler.ru
Ресей, Moscow

R. Ostrovskaya

Zakusov Institute of Pharmacology

Email: alekseyshulkin@rambler.ru
Ресей, Moscow

M. Uzbekov

Moscow Institute of Psychiatry

Email: alekseyshulkin@rambler.ru
Ресей, Moscow

M. Shishkin

Pirogov National Medical Surgery Center

Email: alekseyshulkin@rambler.ru
Ресей, Moscow

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