The effects of prenatal hyperhomocysteinemia on the formation of memory and the contents of biogenic amines in the rat hippocampus


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

We evaluated the long-term neurophysiological effects of prenatal hyperhomocysteinemia (HHC) in mature female rats whose mothers received an oral methionine load daily from the fourth day of pregnancy to delivery. We have shown that after the experimentally induced prenatal HHC in mature female rats, shortterm and long-term memory were disrupted. These changes were observed in the absence of exogenous methionine intake and after recovery of normal values of homocysteine in the serum of rats in comparison with the level detected immediately after birth. A significant reduction in the concentration of noradrenaline, serotonin, and 5-hydroxyindoleacetic acid in the hippocampus of mature female rats subjected to prenatal HHC was also found, which may be one of the causes of their cognitive impairment.

Авторлар туралы

A. Shcherbitskaya

Sechenov Institute of Evolutionary Physiology and Biochemistry; Aff4

Хат алмасуға жауапты Автор.
Email: nastusiq@gmail.com
Ресей, St. Petersburg, 194223; prosp. Toreza 44, St. Petersburg, 194223

Yu. Milyutina

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: nastusiq@gmail.com
Ресей, St. Petersburg

I. Zaloznyaya

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: nastusiq@gmail.com
Ресей, St. Petersburg

A. Arutjunyan

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Email: nastusiq@gmail.com
Ресей, St. Petersburg

N. Nalivaeva

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: nastusiq@gmail.com
Ресей, St. Petersburg, 194223

I. Zhuravin

Sechenov Institute of Evolutionary Physiology and Biochemistry; St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation

Email: nastusiq@gmail.com
Ресей, St. Petersburg, 194223; St. Petersburg

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Pleiades Publishing, Ltd., 2017