Involvement of CA1 GABAA Receptors in Ketamine-Induced Impairment of Spatial and Non-Spatial Novelty Detection in Mice
- Authors: Khanegheini A.1, Meftahi G.H.2, Zarrindast M.R.1, Afarinesh M.R.3, Sahraei H.2, Jahromi G.P.2, Shahyad S.2
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Affiliations:
- Institute for Cognitive Science Studies (ICSS)
- Neuroscience Research Center
- Kerman Neuroscience Research Center, Institute of Neuropharmachology
- Issue: Vol 13, No 1 (2019)
- Pages: 81-89
- Section: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211666
- DOI: https://doi.org/10.1134/S1819712419010094
- ID: 211666
Cite item
Abstract
Inhibitory GABAergic and excitatory glutamatergic neurons from multiple brain areas, send fibers to the hippocampal CA1 region. NMDA receptors have been identified as important compoents of the brain system underlying memory formation, which that through an increase in glutamate-mediated neurotransmission. Ketamine and other NMDA receptor antagonists produce deficits in cognitive tasks, including both spatial and non-spatial memory. In the current study, we tested whether the activation or inhibition of GABAA receptors in CA1 hippocampal of mice has an impact on ketamine (NMDA antagonist) induced spatial and non-spatial novelty detection deficits. Adult male mice weighing between 25–30 g were used. The open-field method was used to evaluate spatial and non-spatial memory information. Data obtained from the present study revealed that an intra-CA1 injection with a sub-threshold dose the GABAA receptor antagonist bicuculline (0.0625 µg mouse) disrupted spatial memory but restored non-spatial memory induced by lower and higher doses of ketamine (0.05 and 0.01 mg/kg) respectively. Meanwhile, the co-administration of the intra-CA1 injection with a sub-threshold dose of muscimol (GABAA receptor agonist at 0.25 µg/mouse) and a lower dose of ketamine could only impair the ability of non-spatial change detection but could not alter spatial novelty. In conclusion, ketamine (which contributes to the impairment of memory trace stored in the hippocampus) may be generated from GABAA receptors of CA1 neurons and their blockade could prevent these effects.
Keywords
About the authors
Arash Khanegheini
Institute for Cognitive Science Studies (ICSS)
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Tehran
Gholam Hossein Meftahi
Neuroscience Research Center
Author for correspondence.
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Niavaran, Araj st., Tehran
Mohammad Reza Zarrindast
Institute for Cognitive Science Studies (ICSS)
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Tehran
Mohammad Reza Afarinesh
Kerman Neuroscience Research Center, Institute of Neuropharmachology
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Kerman
Hedayat Sahraei
Neuroscience Research Center
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Niavaran, Araj st., Tehran
Gila Pirzad Jahromi
Neuroscience Research Center
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Niavaran, Araj st., Tehran
Shima Shahyad
Neuroscience Research Center
Email: hossein.meftahi@bmsu.ac.ir
Iran, Islamic Republic of, Niavaran, Araj st., Tehran
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