Modeling of acquired postischemic epileptogenesis in cultures of neural cells and tissue

Abstract

We reviewed the literature data on the cellular and molecular mechanisms of postischemic epileptogenesis, which is modeled in a culture of dissociated neurons and organotypic culture of nervous tissue. We summarized the data on the involvement of glutamate excitotoxicity in the development of epileptiform discharges generated by neurons in culture after glutamate application and on the involvement of neuronal calcium overload in the formation of seizure activity. We also presented data on the effects of neuroprotectors in models of postischemic epileptogenesis in vitro.