The neurochemical bases of the pharmacological activity of ligands of monoamine-transport systems
- Authors: Golovko A.I.1, Bonitenko E.Y.1, Ivanov M.B.1, Barinov V.A.1, Zatsepin E.P.1
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Affiliations:
- Institute of Toxicology
- Issue: Vol 10, No 3 (2016)
- Pages: 173-183
- Section: Review Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211065
- DOI: https://doi.org/10.1134/S1819712416030065
- ID: 211065
Cite item
Abstract
We review the transport systems of the monoamines dopamine, noradrenaline, and serotonin, which are localized in cytoplasmic membranes and the membranes of synaptic vesicles. We present information on the structure of the transporters and the mechanisms of their functioning. Ligands of the transport systems of monoamines include medications and drugs with psychostimulatory action. The most important neurochemical characteristics of ligands of monoamine transport systems is their affinity to transporters and the ability to inhibit reuptake of neuromediators or, in contrast, initiate a reverse current of neurotransmitters. This is the basis of the pharmacological activities of the considered substances.
About the authors
A. I. Golovko
Institute of Toxicology
Author for correspondence.
Email: prgolovko@inbox.ru
Russian Federation, St. Petersburg
E. Yu. Bonitenko
Institute of Toxicology
Email: prgolovko@inbox.ru
Russian Federation, St. Petersburg
M. B. Ivanov
Institute of Toxicology
Email: prgolovko@inbox.ru
Russian Federation, St. Petersburg
V. A. Barinov
Institute of Toxicology
Email: prgolovko@inbox.ru
Russian Federation, St. Petersburg
E. P. Zatsepin
Institute of Toxicology
Email: prgolovko@inbox.ru
Russian Federation, St. Petersburg
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