Synthesis and evaluation of antimicrobial activity of new 1,3,5-triazine derivatives
- Авторлар: Kuvaeva E.V.1, Levshukova P.O.1, Kolesnik D.A.1, Kirillova E.N.1, Yakovlev I.P.1, Ladutko Y.M.1
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Мекемелер:
- Saint-Petersburg State Chemical and Pharmaceutical University
- Шығарылым: Том 25, № 7 (2022)
- Беттер: 39-43
- Бөлім: Articles
- URL: https://ogarev-online.ru/1560-9596/article/view/143453
- DOI: https://doi.org/10.29296/25877313-2022-07-06
- ID: 143453
Дәйексөз келтіру
Аннотация
Aim. Synthesis of new 1,3,5-triazine derivatives (studied compounds, target compounds) and evaluation of their antimicrobial activity in silico and in vitro. Material and methods. The target compounds were obtained as a result of the reaction of 2,5-disubstituted-4-hydroxy-6H-1,3-oxazin-6-ones and S-methylisothiourea hemisulfate in the presence of an equimolar amount of sodium methylate in a methanol medium. The structure has been proven using modern physico-chemical analysis methods. Computer screening of biological activity was carried out using the PASS program located on the web service and accessible via the Internet. Experimentally, the antimicrobial activity of the compounds was studied in relation to the test culture of the microorganism - Staphylococcus aureus P209. Results. New derivatives of 1,3,5-triazine were synthesized with a yield of 66-72%. The structure of the obtained compounds was proved using 1H and 13C NMR spectroscopy, IR spectroscopy. As a result of screening of biological activity using the PASS program, data on a pronounced antimicrobial effect were obtained. The study of antimicrobial activity in vitro showed that the target compounds have an effect on Staphylococcus aureus P209. Conclusion. New derivatives of 1,3,5-triazine - 2-(methylthio)-4-(4-nitrophenyl)-6-ethyl-1,3,5-triazine, 2-(methylthio)-4-phenyl-6-ethyl-1,3,5-triazine, 2-(methylthio)-4-(4-methylphenyl) were synthesized-6-ethyl-1,3,5-triazine. Their structure has been proved using modern physico-chemical analysis methods. The results of computer prediction made it possible to determine the potential biological activity. Experimental microbiological studies have proved that the studied compounds have antimicrobial activity against Staphylococcus aureus P209.
Толық мәтін
##article.viewOnOriginalSite##Авторлар туралы
E. Kuvaeva
Saint-Petersburg State Chemical and Pharmaceutical University
Email: elena.kuvaeva@pharminnotech.com
Ph.D. (Pharm.), Associate Professor, Department of Organic Chemistry
Ресей, Saint-Petersburg, RussiaP. Levshukova
Saint-Petersburg State Chemical and Pharmaceutical University
Email: levshukova.polina@pharminnotech.com
Student
Ресей, Saint-Petersburg, RussiaD. Kolesnik
Saint-Petersburg State Chemical and Pharmaceutical University
Email: denis.kolesnik@spcpu.ru
Ph.D. (Pharm.), Assistant, Department of Organic Chemistry
Ресей, Saint-Petersburg, RussiaE. Kirillova
Saint-Petersburg State Chemical and Pharmaceutical University
Email: eugenia.kirillova@pharminnotech.com
Ph.D. (Chem.), Associate Professor, Department of Organic Chemistry
Ресей, Saint-Petersburg, RussiaI. Yakovlev
Saint-Petersburg State Chemical and Pharmaceutical University
Email: igor.yakovlev@pharminnotech.com
Dr.Sc. (Chem.), Рrofessor, Head of the Department of Organic Chemistry
Ресей, Saint-Petersburg, RussiaYu. Ladutko
Saint-Petersburg State Chemical and Pharmaceutical University
Хат алмасуға жауапты Автор.
Email: yulia.ladutko@pharminnotech.com
Ph.D. (Pharm.), Аssociate Professor, Department of Medicinal Forms Technology
Ресей, Saint-Petersburg, RussiaӘдебиет тізімі
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