Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives


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A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium chloride with aldehydes was suggested. Some of the compounds obtained exhibit antitumor activity in vitro.

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T. Nguyen

Research and Education Center of Pharmacy, Kazan (Volga region) Federal University

Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008

A. Iksanova

Research and Education Center of Pharmacy, Kazan (Volga region) Federal University

Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008

O. Lodochnikova

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences

Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 8 ul. Akad. Arbuzova, Kazan, 420088

Yu. Shtyrlin

Research and Education Center of Pharmacy, Kazan (Volga region) Federal University

编辑信件的主要联系方式.
Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008

M. Pugachev

Research and Education Center of Pharmacy, Kazan (Volga region) Federal University

Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008

R. Pavelyev

Research and Education Center of Pharmacy, Kazan (Volga region) Federal University

Email: Yurii.Shtyrlin@gmail.com
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008

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