Отправить статью по E-mail Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties
- Авторы: Butov G.M.1, Burmistrov V.V.1, Danilov D.V.1, Averin A.D.2, Morisseau C.3, Kodani S.3, Hammock B.D.3
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Учреждения:
- Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
- M. V. Lomonosov Moscow State University
- Department of Entomology and UCD Cancer Center, University of California
- Выпуск: Том 65, № 9 (2016)
- Страницы: 2299-2305
- Раздел: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/239012
- DOI: https://doi.org/10.1007/s11172-016-1581-y
- ID: 239012
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Аннотация
Adamantyl-containing 1,3-disubstituted ureas, bisureas, and biscarbamates containing different spacers between the ureylene or the carbamate groups and the adamantyl radical were synthesized. Their inhibitory activity against soluble epoxide hydrolases of mammals and humans (sEH, E.C. 3.3.2.10) was studied. The compounds were found to possess high inhibitory activity on the level of 0.8—2.7 nmol L–1. A relationship between the inhibitor structure and its activity was established.
Об авторах
G. Butov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Автор, ответственный за переписку.
Email: butov@volpi.ru
Россия, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
V. Burmistrov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Россия, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
D. Danilov
Volzhsky Polytechnic Institute (branch), Volgograd State Technical University
Email: butov@volpi.ru
Россия, 42 ul. Engel´sa, Volzhskiy, Volgograd Region, 404130
A. Averin
M. V. Lomonosov Moscow State University
Email: butov@volpi.ru
Россия, 1 Leninskie Gory, Moscow, 119991
C. Morisseau
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
США, One shields avenue, California, Davis, 95615
S. Kodani
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
США, One shields avenue, California, Davis, 95615
B. Hammock
Department of Entomology and UCD Cancer Center, University of California
Email: butov@volpi.ru
США, One shields avenue, California, Davis, 95615
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