Enviar artigo por via de e-mail A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography
- Autores: Pokrovskiy O.I.1, Kostenko M.O.2, Lunin V.V.1,2
-
Afiliações:
- N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Edição: Volume 66, Nº 11 (2017)
- Páginas: 2190-2193
- Seção: Brief Communication
- URL: https://ogarev-online.ru/1066-5285/article/view/241725
- DOI: https://doi.org/10.1007/s11172-017-2001-7
- ID: 241725
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.
Sobre autores
O. Pokrovskiy
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: oleg.pokrovskiy@supercritical.ru
Rússia, 31 Leninsky prosp., Moscow, 119991
M. Kostenko
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Rússia, Build. 3, 1 Leninskie Gory, Moscow, 119991
V. Lunin
N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: oleg.pokrovskiy@supercritical.ru
Rússia, 31 Leninsky prosp., Moscow, 119991; Build. 3, 1 Leninskie Gory, Moscow, 119991
Arquivos suplementares
