Application of nonionic amphiphiles for increasing solubility in water of alkylated bibenzimidazole derivatives


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Solubilization capacity of a number of nonionic micelle-forming compounds toward 2,2´-bibenzimidazole and its alkylated derivatives was determined by spectrophotometry. It was found that as the hydrophilic lipophilic balance of the studied amphiphiles grows, their solubilization effect toward 2,2´-bibenzimidazoles increases and reaches the highest value in the case of pluronic F127. The conversion of bibenzimidazoles to the cationic form induced by lowering the medium pH improves efficiency of the solubilizers.

Sobre autores

A. Mirgorodskaya

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088

F. Valeeva

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences

Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088

N. Zhukova

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences

Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088

V. Mamedov

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences; Kazan National Research Technological University

Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088; 68 ul. K. Marksa, Kazan, 420015

L. Zakharova

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences; Kazan National Research Technological University

Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088; 68 ul. K. Marksa, Kazan, 420015

O. Sinyashin

A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences; Kazan National Research Technological University

Email: mirgoralla@mail.ru
Rússia, 8 ul. Akad. Arbuzova, Kazan, 420088; 68 ul. K. Marksa, Kazan, 420015

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