Structure and dynamics of photoactivatable adenylyl cyclase
- Авторлар: Kulakova A.M.1, Khrenova M.G.1,2, Nemukhin A.V.1,3
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Мекемелер:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Шығарылым: Том 68, № 11 (2019)
- Беттер: 1991-1996
- Бөлім: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/243518
- DOI: https://doi.org/10.1007/s11172-019-2657-2
- ID: 243518
Дәйексөз келтіру
Аннотация
The full-atom 3D model of the dimer of the photoregulated adenylyl cyclase is constructed. It contains a molecule of flavin mononucleotide chromophore in the photoreceptor domain and a molecule of adenosine triphosphate substrate in the catalytic domain of each monomer. The performed molecular dynamics simulations show that monomers in the dimer are not equivalent, as well as that the conformation of the dimer changes upon substrate binding to the active site and also after transition of the photoreceptor domain from the dark to the light form.
Авторлар туралы
A. Kulakova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: izvan@ioc.ac.ru
Ресей, Build. 3, 1 Leninskye Gory, Moscow, 119991
M. Khrenova
Department of Chemistry, M. V. Lomonosov Moscow State University; Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: izvan@ioc.ac.ru
Ресей, Build. 3, 1 Leninskye Gory, Moscow, 119991; Build. 2, 33 Leninsky prosp., Moscow, 119071
A. Nemukhin
Department of Chemistry, M. V. Lomonosov Moscow State University; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: izvan@ioc.ac.ru
Ресей, Build. 3, 1 Leninskye Gory, Moscow, 119991; 4 ul. Kosygina, Moscow, 119334
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