The effect of laminins on chemoresistance of colorectal cancer cells
- Авторлар: Maltseva D.V.1,2, Zakharova G.S.1, Rodin S.A.1,3, Tonevitsky A.G.1
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Мекемелер:
- Scientific Research Center Bioclinicum
- National Medical Research Radiology Center, Ministry of Health of the Russian Federation
- Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Шығарылым: Том 67, № 11 (2018)
- Беттер: 2148-2151
- Бөлім: Brief Communications
- URL: https://ogarev-online.ru/1066-5285/article/view/243205
- DOI: https://doi.org/10.1007/s11172-018-2344-8
- ID: 243205
Дәйексөз келтіру
Аннотация
Earlier, the data on the ability of laminin-332 to protect liver cancer cells from apoptosis caused by doxorubicin, sorafenib, and gefitinib have been obtained. In order to answer the question whether this action of laminins is common for cancer cells of other types, we estimated the effect of several laminin isoforms on the survival of two colorectal cancer cell lines (RKO and SW-480) when treated with chemotherapeutic agents used in the colon cancer therapy (5-fluorouracil, regorafenib, and sorafenib). The data obtained suggest that this action of laminins is not universal and is likely governed by individual features of cancer cells.
Авторлар туралы
D. Maltseva
Scientific Research Center Bioclinicum; National Medical Research Radiology Center, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: dmaltseva@gmail.com
Ресей, 85 Build., 2 ul. Ugreshskaya, Moscow, 115088; 4 ul. Koroleva, Obninsk, 249036
G. Zakharova
Scientific Research Center Bioclinicum
Email: dmaltseva@gmail.com
Ресей, 85 Build., 2 ul. Ugreshskaya, Moscow, 115088
S. Rodin
Scientific Research Center Bioclinicum; Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Email: dmaltseva@gmail.com
Ресей, 85 Build., 2 ul. Ugreshskaya, Moscow, 115088; Stockholm, 17177
A. Tonevitsky
Scientific Research Center Bioclinicum
Email: dmaltseva@gmail.com
Ресей, 85 Build., 2 ul. Ugreshskaya, Moscow, 115088
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