Email this article Metallatranes and hydrometallatranes: their immunotropic and antitumor properties
- Authors: Adamovich S.N.1, Oborina E.N.1
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Affiliations:
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 68, No 9 (2019)
- Pages: 1723-1728
- Section: Full Articles
- URL: https://ogarev-online.ru/1066-5285/article/view/243477
- DOI: https://doi.org/10.1007/s11172-019-2616-y
- ID: 243477
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Abstract
A series of biologically active metallatranes and hydrometallatranes was synthesized via the reaction of biogenic triethanolamine with salts or oxides of the essential metals; their toxicity was determined, and the immunotropic and cytotoxic properties were evaluated. Compounds causing immunostimulatory, immunosuppressive, and also competing effects on the immune response were revealed. A pronounced immunosuppressant, 1-oxovanadatran, exhibits a high and selective cytotoxic effect, inhibiting the growth of B16 melanoma cells by 39–80%, but does not affect the tumor cells of L1210 lymphocytic leukemia, P815 mastocytoma, and Lewis lung carcinoma.
About the authors
S. N. Adamovich
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: mir@irioch.irk.ru
Russian Federation, 1 ul. Favorskogo, Irkutsk, 664033
E. N. Oborina
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: mir@irioch.irk.ru
Russian Federation, 1 ul. Favorskogo, Irkutsk, 664033
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