Email this article Inhibition of acid phospholipase A1 activity by the complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate)
- Authors: Abzaeva K.A.1, Rasulov M.M.2, Zhigacheva I.V.3
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Affiliations:
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
- State Research Institute of Chemistry and Technology of Organoelement Compounds
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 68, No 5 (2019)
- Pages: 1122-1124
- Section: Brief Communications
- URL: https://ogarev-online.ru/1066-5285/article/view/243390
- DOI: https://doi.org/10.1007/s11172-019-2529-9
- ID: 243390
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Abstract
Studies in the atherosclerosis model in rabbits showed that the complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) (zincatrane) modulates lipid metabolism in the liver and reduces activity of a lysosomal lipolytic enzyme of the hydrolase class. Zincatrane was proposed for use as an acid phospholipase A1 inhibitor to increase the resistance of the vascular system to cholesterol and prevent atherosclerosis.
About the authors
K. A. Abzaeva
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: abzaeva@irioch.irk.ru
Russian Federation, 1 ul. Favorskogo, Irkutsk, 664033
M. M. Rasulov
State Research Institute of Chemistry and Technology of Organoelement Compounds
Email: abzaeva@irioch.irk.ru
Russian Federation, 38 Entuziastov shosse, Moscow, 105118
I. V. Zhigacheva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: abzaeva@irioch.irk.ru
Russian Federation, 4 ul. Kosygina, Moscow, 119334
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