Effect of Processes Occurring in the Presence of Metal Catalysts on the Main Characteristics of the Hydrogen Isotope Labeled Organic Compounds Obtained

Resumo

The main deuterium and tritium sources used for preparing hydrogen isotope labeled compounds are presented. The mechanisms of hydrogenation and isotope exchange in organic compounds in the presence of heterogeneous and homogeneous catalysts when using gaseous tritium (or deuterium) or tritium (or deuterium) water are considered. Examples of the participation of solvent protons in introduction of deuterium and tritium into organic compounds by dehalogenation are presented. The problem of selective hydrogenation and dehalogenation is briefly discussed. Particular attention is paid to isotope exchange with deuterium or tritium in the presence of homogeneous iridium catalysts.