Radiochemical and biological characterization of 99mTc-oxiracetam as a model for brain imaging

Resumo

^99mTc-oxiracetam was prepared. It can be used as a radiotracer for brain imaging. Under the optimum conditions (0.5 mg of oxiracetam, 50 μg of SnCl₂·2H₂O, pH 7, room temperature, 30 min), the radio-chemical yield determined by chromatographic methods reached 96%. Biodistribution studies with mice showed that the brain uptake of the complex was 5.1% injected dose per gram (% ID/g) at 5 min post injection. In this parameter, the complex surpasses the commercially available ^99mTc-ECD (4.7% ID/g) and ^99mTc-HMPAO (2.25% ID/g).