Preparation of tritium-labeled modified single-walled carbon nanotubes for pharmacokinetic studies

Resumo

Tritium was introduced by the thermal activation method into samples of single-walled carbon nanotubes modified with diaminotriethylene glycol. Chemical linking of the modifier considerably increased the specific radioactivity of the product. The maximal specific radioactivity was reached when “hot” (2000 K) tritium atoms acted on targets of modified nanotubes kept at 295 K. The main pharmacokinetic parameters of tritium-labeled modified carbon nanotubes upon intravenous administration into mongrel rats chosen as a model were determined.