Email this article Radiosynthesis and Biological Evaluation of 188Re-5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphyrin Complex as a Tumor-Targeting Agent
- Authors: Sanad M.H.1, Farag A.B.2, Saleh G.M.3
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Affiliations:
- Labeled Compounds Department, Hot Laboratories Center
- Pharmaceutical Chemistry Department, Faculty of Pharmacy
- Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
- Issue: Vol 61, No 3 (2019)
- Pages: 347-351
- Section: Article
- URL: https://ogarev-online.ru/1066-3622/article/view/225180
- DOI: https://doi.org/10.1134/S106636221903010X
- ID: 225180
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Abstract
188Re-5,10,15,20-tetra(4-pyridyl)-21H,23H-porphyrin, [188Re]TMPP, a tumor-targeted agent, was prepared. Under optimum conditions, the 188Re-TMPP yield after purification exceeded 98%. Biodistribution studies showed high tumor uptake of the agent within 30 min post injection (17.5 ± 1.1% ID/g) for Swiss Albino mice bearing Ehrlich ascites carcinoma (EAC). [188Re]TMPP can be considered as a highly selective radiotracer for highly replicating solid tumors.
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About the authors
M. H. Sanad
Labeled Compounds Department, Hot Laboratories Center
Author for correspondence.
Email: drsanad74@gmail.com
Egypt, Cairo
A. B. Farag
Pharmaceutical Chemistry Department, Faculty of Pharmacy
Email: drsanad74@gmail.com
Egypt, Giza
G. M. Saleh
Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
Email: drsanad74@gmail.com
Egypt, Cairo
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