Email this article Nuclear-chemical synthesis of tritium-labeled fluorinated isoquinolinium derivatives
- Authors: Shchepina N.E.1, Avrorin V.V.2, Badun G.A.3, Shurov S.N.4, Shchepin R.V.5
-
Affiliations:
- Natural Science Institute
- St. Petersburg State University
- Radiochemistry Chair, Chemical Faculty
- Perm State National Research University
- Medical Center North
- Issue: Vol 59, No 3 (2017)
- Pages: 297-300
- Section: Article
- URL: https://ogarev-online.ru/1066-3622/article/view/223956
- DOI: https://doi.org/10.1134/S1066362217030134
- ID: 223956
Cite item
Open Access
Access granted
Subscription Access
Abstract
The developed nuclear-chemical method allows direct phenylation of the nitrogen atom in the isoquinoline molecule and one-step synthesis of tritium-labeled biomarkers containing previously unknown N-(p-difluorophenyl)isoquinolinium fragment with high radiochemical yield.
About the authors
N. E. Shchepina
Natural Science Institute
Author for correspondence.
Email: neshchepina@mail.ru
Russian Federation, ul. Genkelya 4, Perm, 614990
V. V. Avrorin
St. Petersburg State University
Email: neshchepina@mail.ru
Russian Federation, Universitetskaya nab., 7–9, St. Petersburg, 199034
G. A. Badun
Radiochemistry Chair, Chemical Faculty
Email: neshchepina@mail.ru
Russian Federation, Moscow
S. N. Shurov
Perm State National Research University
Email: neshchepina@mail.ru
Russian Federation, ul. Bukireva 15, Perm, 614990
R. V. Shchepin
Medical Center North
Email: neshchepina@mail.ru
United States, 1161 21st Avenue South, AA-1105, Nashville, TN
Supplementary files
