Synthesis of [18F]-L-DOPA radiopharmaceutical on a modified GE TracerLAB Fx F-E platform

Abstract

A procedure was developed for preparing [¹⁸F]-5-hydroxy-2-fluoro-L-thyrosine ([¹⁸F]-fluoro-L-dihydroxyphenylalanine, [¹⁸F]-L-DOPA) radiopharmaceutical on modified commercially available GE Tracer-LAB Fx F-E platform. This modification can be used for preparing both [¹⁸F]-L-DOPA and any other radiopharmaceuticals by electrophilic radiofluorination. The procedure allows preparation of the product meeting all the requirements of European Pharmacopoeia (8th ed.) for clinical use with the decay-corrected radiochemical yield of 20 ± 3% (n = 3).