Email this article Synthesis of 177Lu-based bioconjugate for radioimmunotherapy and evaluation of its stability in physiological media
- Authors: Nurtdinov E.F.1, Proshin M.A.1, Chuvilin D.Y.1
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Affiliations:
- National Research Centre Kurchatov Institute
- Issue: Vol 58, No 2 (2016)
- Pages: 171-176
- Section: Article
- URL: https://ogarev-online.ru/1066-3622/article/view/223360
- DOI: https://doi.org/10.1134/S1066362216020107
- ID: 223360
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Abstract
Labeling of the conjugated molecule of human serum albumin (HSA) and humanized scFv 4D5 mini-antibody specific to her-2/neu receptor with β-emitting 177Lu radionuclide via p-SCN-benzyl-DTPA chelator was studied. The radioconjugate can be prepared with the decay-corrected radiochemical yield of 82%. The stability of the synthesized complex in physiological solutions (normal saline, human blood serum) was evaluated. The complex is stable in physiological solutions for no less than 10 days.
About the authors
E. F. Nurtdinov
National Research Centre Kurchatov Institute
Author for correspondence.
Email: nurtdinov@list.ru
Russian Federation, pl. Akad. Kurchatova 1, Moscow, 123182
M. A. Proshin
National Research Centre Kurchatov Institute
Email: nurtdinov@list.ru
Russian Federation, pl. Akad. Kurchatova 1, Moscow, 123182
D. Yu. Chuvilin
National Research Centre Kurchatov Institute
Email: nurtdinov@list.ru
Russian Federation, pl. Akad. Kurchatova 1, Moscow, 123182
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