Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells

Abstract

Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia Т cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.