Effect of Gold Nanorods on the Remote Decapsulation of Liposomal Capsules Using Ultrashort Electric Pulses

Аннотация

Decapsulation of nanocomposite liposomal capsules due to the effect of ultrashort electric pulses is obtained when the liposomal sheaths of the capsules are bound to significantly anisotropic gold nanoparticles (nanorods). Destruction of the liposomal sheath is interpreted using the rotational displacement of gold nanorods in the presence of the pulsed electric field. Such an interpretation is used to derive an expression for the critical electric field that determines the threshold level of the effect. The calculated critical field is in agreement with the experimental results. It is shown that the decapsulation is related to the presence of the gold nanorods in the sheath of liposomal capsules and is not obtained in the absence of the nanorods.