Influence of Liposomal Compositions Containing AFP and GCSF Recombinant Human Proteins on Mice Skin Radiation Burn according to Clinical Indicators and Indices of Skin Stem Cells


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Using a IIIA radiation skin burn model in CD1 mice, we demonstrated that transdermal application of liposomes containing rhAFP; liposomes containing rhGCSF; and liposomes containing rhAFP and rhGCSF on the affected area of the skin within two weeks after irradiation led to a significant reduction in the healing time of the burn wound according to clinical indices. The most effective was the use of liposomes containing rhAFP: the duration of the latent period increased 70%, the duration of the moist epidermitis was reduced by 60%, the duration of the reparative phase was reduced by 32%, and the total healing time of the burn was reduced by 44%, compared to the values for mice with untreated radiation burns. Immunohistochemical studies have shown that application of the studied drugs led to an increase in the survival of stem cells in the hair follicles of the skin: the most pronounced effect on histological indices was noted in the group treated with liposomes containing rhAFP and rhGCSF.

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E. Pryakhin

Urals Research Center for Radiation Medicine

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Email: pryakhin@yandex.ru
俄罗斯联邦, Chelyabinsk, 454048

G. Trjapitsyna

Urals Research Center for Radiation Medicine; Chelyabinsk State University

Email: pryakhin@yandex.ru
俄罗斯联邦, Chelyabinsk, 454048; Chelyabinsk, 454001

I. Shaposhnikova

Urals Research Center for Radiation Medicine

Email: pryakhin@yandex.ru
俄罗斯联邦, Chelyabinsk, 454048

M. Tyuhay

Urals Research Center for Radiation Medicine; Chelyabinsk State University

Email: pryakhin@yandex.ru
俄罗斯联邦, Chelyabinsk, 454048; Chelyabinsk, 454001

Yu. Ostroumov

Institute of Engineering Immunology

Email: pryakhin@yandex.ru
俄罗斯联邦, Lyubuchany, Moscow oblast, 142380

P. Shmelin

Central Research Technological Institute “Technomash,”

Email: pryakhin@yandex.ru
俄罗斯联邦, Moscow, 121108

A. Akleev

Urals Research Center for Radiation Medicine; Chelyabinsk State University

Email: pryakhin@yandex.ru
俄罗斯联邦, Chelyabinsk, 454048; Chelyabinsk, 454001

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