The Use of Radioprotective Agents to Prevent Effects Associated with Aging

Resumo

Anti-aging properties can be found in many compounds with radiation-protective effects. Such compounds include the following: bioflavonoids, some antioxidants (N-acetylcysteine), melatonin, some non-steroid anti-inflammatory agents and statins, angiotensin converting enzyme inhibitors, metformin, rapamycin, etc. The effects of the drugs can develop both in the case of their long-term use and in case of a single application against the background of acute exposure to ionizing radiation at lethal doses. At the same time, “classical” radiation-protective agents such as cystamine, amifostine, adrenergic alfa-blockers, and androgenic drugs were not revealed to have geroprotective properties, which may be due to their high toxicity.