LEVELS OF IL-6 AND IFN-γ IN CHILDREN WITH SCHIZOPHRENIA AND AUTHISM SPECTRUM DISORDERS WITH DIFFERENT PHENOTYPES OF SOCIAL BEHAVIOR
- 作者: Filippova Y.Y.1, Burmistrova A.L.1
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隶属关系:
- «Chelyabinsk State University»
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 599-601
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120314
- DOI: https://doi.org/10.31857/S102872210007012-8
- ID: 120314
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详细
The paper presents the results of a study of the levels of important regulatory mediators of neurogenesis and neuroplasticity: IL-6 and IFN-γ in the blood plasma of children with schizophrenia and autism spectrum disorders with diff erent phenotypes of social behavior. Children with schizophrenia have been found to have signifi cantly high levels of the cytokines, both in comparison with typically developing children and with children with autism. The heterogeneous group of children with autism, a feature of which is the partial loss of previously acquired social skills – «Regression», is characterized by intermediate IL-6 and IFN-γ values and, as we assume, can include children with schizophrenia.
作者简介
Yu. Filippova
«Chelyabinsk State University»
编辑信件的主要联系方式.
Email: julse@rambler.ru
PhD, Associate Professor of Department of Microbiology, Immunology and General Biology, Biological Faculty,
Chelyabinsk
俄罗斯联邦A. Burmistrova
«Chelyabinsk State University»
Email: fake@neicon.ru
MD, Professor, Head of Department of Microbiology, Immunology and General Biology, Faculty of Biology,
Chelyabinsk
俄罗斯联邦参考
- Baron-Cohen S. Editorial Perspective: Neurodiversity – a revolutionary concept for autism and psychiatry. J. Child. Psychol. Psychiatry, 2017, 58(6), 744–747.
- Owen M. J., O’Donovan M. C., Thapar A., Craddock N. Neurodevelopmental hypothesis of schizophrenia. Br. J. Psychiatry, 2011, 198(3), 173–175.
- Barlati S., Deste G., Ariu C., Vita A. Autism spectrum disorder and schizophrenia: do they overlap? Int. J. Emerg. Mental Health and Human Res., 2016, 18(1), 760–763.
- Vorstman J. A.S., Burbach J. P.H. Autism and schizophrenia genetic and phenotypic relationships. In book: Comprehensive Guide to Autism. Springer Science & Business Media, New York 2014, P. 1645–1662.
- Goldsmith D. R., Rapaport M. H., Miller B. J. A metaanalysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol. Psychiatry, 2016, 21(12), 1696–1709.
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