AUTOANTIBODIES TO THE MYELIN BASIC PROTEIN IN PATIENTS WITH SCHIZOPHRENIA HAVE PROTEOLYTIC ACTIVITY
- 作者: Parshukova D.A.1, Buneva V.N.2, Kornetova E.G.1, Kazantseva D.V.3, Vasilevа A.R.3, Ivanova S.A.1, Smirnova L.P.1
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隶属关系:
- Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
- Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
- Siberian State Medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 451-454
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120255
- DOI: https://doi.org/10.31857/S102872210006927-4
- ID: 120255
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详细
This work is devoted to the study of the association of MBP-hydrolyzing IgG activity with the level of antibodies to MBP in patients with schizophrenia. In the group of patients, a high level of specifi c proteolytic activity of antibodies (AT) and a twofold increase in the level of antibodies to MBP were found. A signifi cant positive correlation (r=0,48; p=0,026) was found between the studied parameters.
作者简介
D. Parshukova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
编辑信件的主要联系方式.
Email: fake@neicon.ru
Junior scientist of Molecular Genetics and Biochemistry Laboratory,
Tomsk
俄罗斯联邦V. Buneva
Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
Email: fake@neicon.ru
Ph D., Professor, Principal Researcher Laboratory of Reparation Enzymes,
Novosibirsk
俄罗斯联邦E. Kornetova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Email: fake@neicon.ru
Ph D., Leading Researcher Departments of endogenous disorders,
Tomsk
俄罗斯联邦D. Kazantseva
Siberian State Medical University
Email: fake@neicon.ru
Student,
Tomsk
俄罗斯联邦A. Vasilevа
Siberian State Medical University
Email: fake@neicon.ru
Student,
Tomsk
俄罗斯联邦S. Ivanova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Email: fake@neicon.ru
PhD, Professor, Deputy Director (Scientifi c Director) of Mental Health Research Institute,
Tomsk
俄罗斯联邦L. Smirnova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Email: lpsmirnova@yandex.ru
PhD, Senior Researcher of Molecular Genetics and Biochemistry Laboratory,
Tomsk
俄罗斯联邦参考
- Васильев А. Г., Чурилов Л. П., Трашков А. П., Утехин В. И. Эволюция иммунной системы и регуляторные эффекты антител. Цитология. 2018. 60 № 2.
- Невинский Г. А., Канышкова Т. Г., Семенов Д. В., Бунева В. Н. Каталитически активные антитела и их возможная биологическая функция. Вестн. РАМН 2011, № 2, 38–45.
- Лобачева О. А., Ветлугина Т. П., Семке А. В. Иммунологические критерии прогноза эффективности антипсихотической терапии больных шизофренией. Сиб. вестн. псих. и наркол. 2013, № 1 (76), 66–70.
- Клюшник Т. П., Козловская Г. В., Калинина М. А., Сарманова З. В., Отман И. Н. Динамика содержания антител к нейроантигенам в сыворотке крови больных шизофренией в процессе терапии. Журнал невр. и псих. им. С. С. Корсакова. 2008, Т. 108, № 8, 61–65.
- Parshukova D., Smirnova L. P., Ermakov E. A., Bokhan N. A., Semke A. V., Ivanova S. A., Buneva V. N., Nevinsky G. A. Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein. J Mol Recognit., 2019, 32.2: e2759.
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