sIgE TO BACTERIAL ALLERGENES IN PATIENTS WITH CHRONIC INFLAMMATORY PULMONARY DISEASES
- 作者: Mazurina S.A.1, Konishcheva A.Y.1, Ospelnikova T.P.1, Gervazieva V.B.1
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隶属关系:
- Mechnikov Research Institute for Vaccines and Sera
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 388-390
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120080
- DOI: https://doi.org/10.31857/S102872210006906-1
- ID: 120080
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全文:
详细
Infections colonization colonization of the bronchopulmonary biotope is considered as one of the likely factors for maintaining the inflammatory process with a predominance of the Th2 immune response in patients with chronic diseases of the lung airway. The aim of the study was to assess the IgE immune response to the main microorganisms lung airway. Patients and methods: In the blood serum of 69 patients with BA, COPD and АСОS, the content of total IgE and sIgE for bacterial allergens, sIgA level in saliva was determined by ELISA. Results. In patients with АСОS, a wider spectrum of sIgE to bacterial allergens is presented, against the background of reduced levels of sIgA in saliva, in comparison with patients with asthma and COPD. This may indicate the involvement of innate immunity due to the IgE system in relation to anti-infective protection in patients with АСОS.
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作者简介
S. Mazurina
Mechnikov Research Institute for Vaccines and Sera
编辑信件的主要联系方式.
Email: svetulyok@list.ru
Ph.D., Leading Researcher at the lab. allergodiagnostic,
俄罗斯联邦
A. Konishcheva
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Ph.D., Leading Researcher at the lab. allergodiagnostic,
俄罗斯联邦
T. Ospelnikova
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Ph.D., Head. of the lab. Interferons,
俄罗斯联邦
V. Gervazieva
Mechnikov Research Institute for Vaccines and Sera
Email: fake@neicon.ru
Prof., MD, Head of the Department of Allergology,
俄罗斯联邦
参考
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- Мазурина С. А., Данилина Г. А., Смирнова М. Ю., Осипова Г. Л., Гервазиева В. Б., Конищева А. Ю., Оспельникова Т. П. Микробиота нижних отделов дыхательных путей при хронических обструктивных заболеваниях легких. Журнал микробиологии, эпидемиологии и иммунобиологии. 2018; (5): 53– 60.
- Hizawa N. Clinical approaches towards asthma and chronic obstructive pulmonary disease based on the heterogeneity of disease pathogenesis. Clin Exp Allergy. 2016 May;46(5):678–87.
- Железникова Г. Ф. Иммуноглобулин Е: биологическая роль при инфекционных заболеваниях. Медицинская иммунология. 2002; 4 (4–5): 515–534.
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