CD4+ T-LYMPHOCYTE FUNCTION IS VIOLATED IN HIV-INFECTED PATIENTS WITH DISCORDANT RESPONSE TO ANTIRETROVIRAL THERAPY
- 作者: Korolevskaya L.B.1, Saidakova E.V.1
-
隶属关系:
- Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 329-331
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119896
- DOI: https://doi.org/10.31857/S102872210006617-3
- ID: 119896
如何引用文章
全文:
详细
In HIV-infected patients with a discordant response to antiretroviral therapy, CD4+ T-cell proliferative capacity, ability to synthesize IL-2, and resistance to apoptosis were accessed. It was shown that in those subjects, CD4+ T-cells are characterized by a decreased mitotic activity and IL-2 production; and an increased rate of programmed death. Disorders found could be the basis for the ineff ective CD4+ Tcell counts restoration in patients with a discordant response to the treatment.
作者简介
L. Korolevskaya
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: bioqueen@mail.ru
PhD, research scientist of the Laboratory of Ecological Immunology,
Perm
俄罗斯联邦E. Saidakova
Institute of Ecology and Genetics of Microorganisms Ural Branch of the Russian Academy of Sciences
PhD, junior research scientist of the Laboratory of Ecological Immunology,
Perm
俄罗斯联邦参考
- Autran B, Carcelaint G., Li T. S., Blanc C., Renaud M., Durali M., Mathez D., Calvez V., Leibowitch J., Katlama C., Debre P. Restoration of immune system with anti-retroviral therapy. Immunol. Lett. 1999, 66, 207–211.
- Massanella M., Negredo E., Clotet B., Blanko J. Immunodiscordant responses to HAART – mechanisms and consequences/ Expert Rev/ Clin. Immunol. 2013, 9, 1135–1149.
- Сайдакова Е. В., Шмагель К. В., Королевская Л. Б., Шмагель Н. Г., Гуляева Н. И., Фрейнд Г. Г., Южанинова С. В., Черешнев В. А. Пролиферация CD4+ Т-лим фо цитов пр развитии дискордантного ответа иммунной системы на антиретровирусную терапию у ВИЧ-ин фи ци ро ван ных больных. Цитология, 2018, 60(12), 1029–1036.
- Bocharov G., Luzyanina T., Cupovic J., Ludewig B. Asymmetry of cell division in CFSE-based lymphocyte proliferation analysis. Front. Immunol. 2013, 4, 264.
- Hansjee N., Kaufmann G. R., Strub C., Weber R., Battegay M., Erb P., and the Swiss HIV Cohort Study. Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes. J. Acquir. Immune. Defic. Syndr, 2004, 36, 671–677.
补充文件
