RECEPTOR FUNCTIONS OF SEMA4D IN THE CONTROL OF T-LYMPHOCYTE PROLIFERATION
- 作者: Kuklina E.M.1
-
隶属关系:
- “Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 840-842
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119720
- DOI: https://doi.org/10.31857/S102872210006679-1
- ID: 119720
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详细
Сlass IV semaphoring Sema4D is widely represented in the immune system, both in membrane and in soluble form, and controls immune processes, realizing its effects through specific receptors ‒ these are generally accepted ideas. This paper presents data indicating the presence of an alternative way of Sema4D involvingin immunoregulation: this way suggests the functioning of membrane semaphorin as a receptor, which conducts a signal into the cell it is expressed on. Possible signaling mechanisms from membrane Sema4D are discussed.
作者简介
E. Kuklina
“Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
编辑信件的主要联系方式.
Email: ibis_07@mail.ru
Doctor of Biology, Leading Researcher, Laboratory of Immunoregulation,
Perm
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