THE CONDITION OF SYSTEMIC IMMUNITY IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS AND HUMAN PAPILLOMA VIRUS
- 作者: Zaynetdinova L.F.1, Koryaushkina A.V.1, Telesheva L.F.1
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隶属关系:
- South Ural State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 251-253
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119680
- DOI: https://doi.org/10.31857/S102872210006591-5
- ID: 119680
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详细
Genital endometriosis is an estrogen-dependent inflammatory disease, the etiology of which is not known. Given the high prevalence of HPV among women of reproductive age, as well as the development of endometriosis mainly in the same age group, we can assume the participation of HPV in the formation of features of systemic immunity in this disease. The results of the study showed the presence of HPV in 13 (18,8%) women with 1–2 stages of endometriosis and in 22 (24,4%) – with 3–4 stages of endometriosis. In the presence of HPV in women with 1–2 stages of endometriosis, it was established: an increase in the relative number of T-NK lymphocytes, a decrease in IL-2, IL-6 and an increase in serum IL-4, TNFα, IFNγ. With 3–4 stages – an increase in the absolute number of T-NK-lymphocytes, IL-4, IL-8, IL-10, TNFα, IFNγ in serum. Thus, in women with endometriosis in the presence of HPV, the features of systemic immunity have been identified, which may be associated with disease progression.
作者简介
L. Zaynetdinova
South Ural State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: sea-gull6@yandex.ru
Department of Obstetrics and Gynecology, South Ural State Medical University, Ministry of Health of the Russian Federation,
Chelyabinsk
俄罗斯联邦A. Koryaushkina
South Ural State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
clinic,
Chelyabinsk
俄罗斯联邦L. Telesheva
South Ural State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,
Chelyabinsk
俄罗斯联邦参考
- Matarese G., De Placido G., Nicas Y., Alviggi C. Patogenesis of endometriosis: natural immunity disfunction or autoimmune disease.// Trends Mol.Med.2003Vol. 9.№ 5. – P. 223–228.
- Kobayashi H., Higashiura Y., Shigetomi H., Kajihara H. Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation (Review). Mol Med Rep 2014; 9: 9–15.
- Oppelt P., Renner S. P., Strick R., Valletta D., Mehlhorn G., Fasching P. A. et al. Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions. Fertility and Sterility. 2010; 93(6): 1778–86. doi: 10.1016/j.fertnstert.2008.12.061.
- Heidarpour M., Derakhshan M., Derakhshan-Horeh M., Kheirollahi M., Dashti S. Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. J. Obstet Gynaecol Res. 2017 Jan; 43(1): 135–139. doi: 10.1111/jog.13188.
- Эндометриоз: диагностика, лечение и реабилитация. Федеральные клинические рекомендации по ведению больных. Москва, 2016: 66с.
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