Email this article Genetic aspects of neurogenic syncopes
- Authors: Ismagilov M.F.1, Gainetdinova D.D.1
-
Affiliations:
- Kazan Order of the Red Banner of Labor Medical Institute named after S.V.Kurashov
- Issue: Vol XXV, No 1-2 (1993)
- Pages: 19-22
- Section: Original article
- URL: https://ogarev-online.ru/1027-4898/article/view/105916
- DOI: https://doi.org/10.17816/nb105916
- ID: 105916
Cite item
Full Text
Abstract
The incidence of syncopal states in representative choice of 3209 Kazan pupils is improved, and the role of hereditary factors in the genesis of neurogenic syncopes based on the clinicogenealogical analysis of 115 families using mathematical- and-genetic investigation methods is defined concretely. As many as 91.4% syncopal states in the population studied are assessed as neurogenic syncopes (population rate — 6.4%). The disease may be assigned to the familial forms of pathology conforming to the basic characteristics of multifactorial diseases with sufficiently high (73.5%) role of genetic factors. In case of the marriage of parents «patient-patient» the observed segregational rate (0.43) of neurogenic syncopes approaches the expected one (0.50) which does not eliminate the dominant model of monogenous disease.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
M. F. Ismagilov
Kazan Order of the Red Banner of Labor Medical Institute named after S.V.Kurashov
Author for correspondence.
Email: info@eco-vector.com
Professor, Head of the Department of Neuropathology, Neurosurgery and Medical Genetics
Russian Federation, KazanD. D. Gainetdinova
Kazan Order of the Red Banner of Labor Medical Institute named after S.V.Kurashov
Email: info@eco-vector.com
Department of Neuropathology, Neurosurgery and Medical Genetics
Russian Federation, KazanReferences
- Акимов Г.А., Ерохина Л.Г., Стыкан О.А.// Неврология синкопальных состояний. - М.,1987.
- Бочков Н.П., Захаров А.Ф., Иванов И.В.// Медицинская генетика. - М.,1984.
- Заболевания вегетативной нервной системы. Руководство для врачей (под ред. А.М.Вейна)// - М.,1991.
- Коровин А.М.// Судорожные состояния у детей. - М.,1984.
- Эдвардс Ж.// Доклады научной группы ВОЗ: Методология семейно-генетических факторов. - Женева,1972.
- Carter C.О.// An ABC of medical genetics. - Boston,1969.
- Edwards J.N.// Brit.Med.Bu Bull. - 1969. - Vol.1. - P.59- 67.
- Falconer D.// Ann.Hum.Genet. - 1965. - Vol.29. - P.51-76.
Supplementary files
