N.N. Priorov Journal of Traumatology and Orthopedics
type: channel
description: ISSN (print): 0869-8678, ISSN (online): 2658-6738 Founder: National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov Editor-in-Chief: Sergey P. Mironov, academician of RAS, Doctor of Sc. Frequency / Access: 4 issues per year / Subscription Included in: White List (4th level), Higher Attestation Commission List, RISC
publisher: Eco-Vector
language: ru-RU
publication name: N.N. Priorov Journal of Traumatology and Orthopedics
issn: 0869-8678
copyright: Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal exclusive license to first publication. Authors are able to distribute the manuscript and/or the article in accordance with Self-Archiving policy of the journal (see details). The manuscript can be accepted for publication only by decision of the Editor-in-Chief and the Editorial board of the journal in accordance with the Manuscript stelection policy of the journal (see details). Published Article will be distributed in print and electronic version an will be available under subscription with Delayed Open Access or in Immediate Open Access under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). The access model depends on the publisher's decision or is determined by a separate Open Access publishing agreement with the authors. An exclusive license for publication granted by authors allows the publisher to use the article in the following ways: Reproduction of the Article or its sections or parts, as well as the metadata of the Article in any languages, in any material form, including on paper and electronic media, as a separate work in the journal and/or databases (local or in the Internet) of the publisher and/or other persons, at the discretion of the publisher; Distribution of the Article or its sections or parts, as well as the metadata of the Article in any languages, on any medium as part of the journal and/or databases of the publisher or other persons, at the discretion of the publisher, or as an independent work around the world whether on Open-Access terms or for a fee without remuneration to the Author; Making the Article or any of its sections or parts, as well as the Article’s metadata in any languages, publicly available in such a way that any person can access the Article from any place, including via the Internet, and at any time of their own choosing; Granting permission/s for the…
items: Retrospective multicenter study of injuries associated with personal mobility devices in Moscow
items: Surgical management of proximal humeral fractures
items: Reverse shoulder arthroplasty for glenoid deformities: a retrospective cohort study
items: Early minimally invasive drainage in nonspecific lumbar spondylodiscitis
items: Decision support system for the treatment of surgical site infections in trauma and orthopedic patients
items: Results of a six-year monitoring of antimicrobial resistance in major pathogens of fracture-related infection of long bones and chronic osteomyelitis following transosseous osteosynthesis
items: Modeling a clinical instrumental system for objective assessment of foot function in patients with post-traumatic deformity of the ankle and calcaneus
items: Evaluation of the wear rate of the acetabular component in total hip arthroplasty using russian ultra-high-molecular-weight polyethylene
items: Genetic risk factors for musculoskeletal injuries and disorders in athletes of the national teams of the Russian Federation
items: Diagnosing low-grade central osteosarcoma using a neural network mathematical model: a case report and review
items: Radiofrequency echographic multispectrometry: a promising method for the diagnosis of osteoporosis and the assessment of low-energy fracture risk

Retrospective multicenter study of injuries associated with personal mobility devices in Moscow
type: item
description: BACKGROUND: The use of personal mobility devices is associated with a high risk of injury, with the number of injuries increasing in direct proportion to the growing popularity of personal mobility devices and the number of trips taken. This situation necessitates research into injury patterns to enable the implementation of preventive measures and the development of unified treatment algorithms. Russian scientific sources mainly present isolated data based on small samples, which complicates analysis and systematization. AIM: This study aimed to assess the level, distribution, and temporal changes of injuries associated with personal mobility devices in the largest Russian metropolis (Moscow); to identify trends and risk factors affecting the safety of personal mobility devices operation; and to initiate the systematization of clinical data on personal mobility device-related injuries across the Russian Federation. METHODS: It was a multicenter, non-randomized, retrospective, anonymized study of personal mobility device-related injuries. The analysis was based on reports and medical records from patients treated in 5 outpatient and 7 inpatient facilities of the Moscow City Health Department. The study sample comprised 4678 patients aged 18–89 years, divided into two groups: the first included 3302 patients (70%) who received outpatient medical care or refused hospitalization, and the second included 1376 patients (30%) who were admitted for inpatient treatment. Methods of retrospective analysis, stratification, and statistical data processing were applied. RESULTS: Hospitalized patients accounted for 1376 cases (30%), with a mean age of 35 years (range: 18–86). Most participants were of working age, of both sexes, with no marked gender predominance. However, hospitalized patients were significantly older than outpatients (p < 0.05). The gender distribution did not differ between groups (p > 0.05). In the group hospitalized for inpatient treatment, injuries resultin…
creator: Anton G. Nazarenko
creator: Maxim V. Naumenko
creator: Aleksandr A. Ochkurenko
creator: Elena B. Kleimenova
creator: Liubov P. Yashina
creator: Stanislav E. Maletin
creator: Damir R. Davydov
creator: Aleksandra V. Rogoschenkova
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-09
publication date: 2025-10-09
volume: 32
number: 4
starting page: 744
ending page: 751
doi: 10.17816/vto690044

Surgical management of proximal humeral fractures
type: item
description: BACKGROUND: Current clinical guidelines for the treatment of proximal humeral fractures standardize each case based solely on the type of injury. However, there is no systemic approach to the choice between performing humeral osteosynthesis or shoulder arthroplasty, based on a comprehensive assessment of objective diagnostic criteria. AIM: The work aimed to develop a diagnostic algorithm with the aim of enabling a differentiated approach to the surgical treatment of proximal humeral fractures. METHODS: This pilot, single-center, cohort, retrospective, observational study with a complete sample compared quantitative and qualitative data from two groups of patients. Outcomes of 50 patients with proximal metaepiphyseal humeral fractures treated surgically between 2019 and 2022 were analyzed. All patients underwent multislice computed tomography of the shoulder joint. Computed tomography data were used to calculate Hounsfield units of the humeral fracture fragments. Prognostically, Hounsfield units values below 65, corresponding to significant reduction in bone density due to regional or systemic osteoporosis, indicated a poor outlook for osteosynthesis, with elevated risks of implant instability, secondary fragment displacement, and nonunion of the fracture site. In cases with satisfactory bone density values, osteosynthesis techniques for humeral fractures were applied. Reverse shoulder arthroplasty was performed in patients with fractures unsuitable for reconstruction. Functional, clinical, and radiological outcomes of surgical treatment were assessed in both groups. Functional and clinical outcomes were evaluated using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. RESULTS: Retrospective follow-up showed no adverse osteosynthesis outcomes such as nonunion or avascular necrosis of the fragments. No purulent-inflammatory complications occurred. Fracture consolidation was achieved, and favorable functional outcomes were observed in all patients tr…
creator: Gurgen A. Kesyan
creator: Grigoriy S. Karapetyan
creator: Artyom A. Shuyskiy
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 752
ending page: 762
doi: 10.17816/vto634708

Reverse shoulder arthroplasty for glenoid deformities: a retrospective cohort study
type: item
description: BACKGROUND: Reverse shoulder arthroplasty is increasingly becoming the standard surgical treatment for shoulder joint conditions. To our knowledge, in cases of glenoid deformities, lateralization of the scapular component of the shoulder prosthesis plays an important role. Several methods are used to achieve the scapular component lateralization, one of which is the use of a patient-specific metallic augment. We present the treatment outcomes of patients who underwent standard reverse shoulder arthroplasty without glenoid modeling versus those treated with a patient-specific metallic augment. AIM: The work aimed to evaluate the outcomes of reverse shoulder arthroplasty performed using the standard technique and with a patient-specific metallic augment in patients with glenoid deformities. METHODS: It was a single-center retrospective cohort study. Between 2019 and 2024, 62 patients with scapulohumeral osteoarthritis and associated glenoid deformities were treated in the Department of Traumatology and Orthopedics No. 1 of the N.N. Priorov National Medical Research Center of Traumatology and Orthopedics (Moscow). A total of 31 patients underwent standard reverse shoulder arthroplasty, whereas the remaining 31 received implantation of a patient-specific metallic augment manufactured using additive technologies. Demographic and radiographic data, surgical technique, operative time, blood loss, and complications were recorded. Patients were followed up at 6 weeks, 3 months, 6 months, and 1 year postoperatively. Functional outcomes were assessed using the ASES, DASH, UCLA, Constant, and VAS scores. RESULTS: Of the 62 patients, 19 (30.64%) were men and 43 (69.36%) were women. Glenoid deformities were classified according to Walch as B1 in 31, B2 in 19, and B3 in 12 patients. The abduction angle was 120.6 ± 6.9° at the first postoperative assessment and 173.2 ± 6.8° at the final follow-up, compared with 83.4 ± 12.8° preoperatively (p < 0.05). In the patient-specific metalli…
creator: Ivan N. Marychev
creator: Yago G. Gudushauri
creator: Mikhail B. Tsykunov
creator: Evgeniy Yu. Fedotov
creator: Vyacheslav V. Konovalov
creator: Alexander D. Lamasov
creator: Sergey S. Stoyukhin
creator: Ivan A. Chugreev
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 763
ending page: 779
doi: 10.17816/vto677074

Early minimally invasive drainage in nonspecific lumbar spondylodiscitis
type: item
description: BACKGROUND: The effectiveness of minimally invasive puncture drainage of the destruction zone and paravertebral abscesses in nonspecific pyogenic spondylodiscitis has not been sufficiently studied. AIM: To evaluate the effectiveness of treating acute nonspecific lumbar spondylodiscitis by percutaneous drainage of the inflammatory focus with targeted antibiotic therapy compared with conventional empirical antibiotic therapy followed by surgical treatment. METHODS: A single-center, retrospective, controlled, cohort pilot study analyzed qualitative data from 63 patients (33 women and 30 men, mean age 56.79 years) with primary nonspecific monosegmental (39 patients) and polysegmental (24 patients) lumbar spondylodiscitis. A total of 34 patients underwent empirical antibiotic therapy followed by open debridement, whereas 29 patients received early minimally invasive debridement with percutaneous drainage of the destroyed disc and psoas abscess followed by targeted antibiotic therapy. Vertebral involvement was assessed according to the Pola classification. Neurological status, laboratory parameters including bacteriological tests, duration of hospital stay, and findings of magnetic resonance imaging and computed tomography were evaluated. Functional status was assessed using the Visual Analog Scale for pain, the Rivermead Mobility Index, and the Oswestry Disability Index at baseline and at the end of treatment. Follow-up lasted at least 6 months after discharge. RESULTS: In acute nonspecific vertebral osteomyelitis, early (within the first 24 hours of admission) percutaneous biopsy of the lesion with closed drainage, compared with empirical antibiotic therapy with subsequent surgery in cases of failure, increased pathogen verification from 41.1% to 89.7% (p < 0.01), reduced overall treatment duration from 71.1 ± 16.6 to 46.3 ± 18.3 days (p < 0.01), and decreased the risk of delayed segmental instability from 41.0% to 20.6% (p < 0.01), with comparable mortality, hospital s…
creator: Vladimir V. Dyukarev
creator: Alexander Yu. Mushkin
creator: Nikolay I. Shevchenko
creator: Svetlana M. Yudina
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 780
ending page: 788
doi: 10.17816/vto642384

Decision support system for the treatment of surgical site infections in trauma and orthopedic patients
type: item
description: BACKGROUND: Despite the availability of clinical guidelines for managing patients with surgical site infections, data on the adherence of real clinical practice to these protocols in Russian hospitals remain limited. Data on how noncompliance with clinical guidelines influences outcomes in patients with surgical site infections are also limited. AIM: This study aimed to develop a clinical decision support system for personalized selection of surgical strategies and antibiotic therapy in surgical site infections, and to evaluate adherence of the provided therapy to clinical guidelines for the diagnosis and treatment of surgical site infections in trauma and orthopedic practice. METHODS: It was a single-center retrospective continuous uncontrolled observational study of data from patients hospitalized at the N.N. Priorov National Medical Research Center of Traumatology and Orthopedics, Ministry of Health of Russia, between January 2024 and May 2025. Eligible patients had clinical signs of postoperative wound inflammation, fever (body temperature > 37.5 °C) persisting for three or more days after surgery, a positive wound culture, or a consultation with a clinical pharmacologist regarding antibiotic therapy. The study endpoints included compliance of surgical strategy and antibiotic therapy with clinical guidelines (choice of drug, dosage, and duration). Adherence to therapy was assessed by comparing prescriptions with approved surgical site infection treatment protocols using the clinical decision support system. Compliance with guidelines was analyzed in the overall cohort as well as in subgroups of acute and chronic infection. RESULTS: The study included 90 patients, of whom 84 met surgical site infection criteria (31 with acute and 53 with chronic surgical site infections). Full adherence to clinical guidelines was observed in 20 cases (24%) (13 acute, 7 chronic). In 25 cases (30%), the choice of antimicrobial agent did not comply with the recommended one; in 7 cas…
creator: Anton G. Nazarenko
creator: Elena B. Kleimenova
creator: Natalia I. Sobur
creator: Archil V. Tsiskarashvili
creator: Mikhail A. Dronov
creator: Vitaly A. Otdelenov
creator: Ekaterina S. Yurchenkova
creator: Liubov P. Yashina
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 789
ending page: 798
doi: 10.17816/vto689174

Results of a six-year monitoring of antimicrobial resistance in major pathogens of fracture-related infection of long bones and chronic osteomyelitis following transosseous osteosynthesis
type: item
description: BACKGROUND: The growing resistance of pathogenic strains involved in fracture-related infection substantially limits the effectiveness of antibiotic therapy and represents a serious public health concern. AIM: This study aimed to determine and assess trends in antimicrobial resistance of the major pathogens isolated from patients with long bone fracture-related infection and chronic osteomyelitis, as its sequela, treated with transosseous osteosynthesis between 2019 and 2024. METHODS: An observational, single-center, retrospective analysis of antimicrobial resistance patterns of the major pathogens isolated from 247 patients treated between 2019 and 2024 was performed. The obtained data were statistically analyzed using Pearson’s χ2 test. RESULTS: More than 60% of methicillin-susceptible Staphylococcus aureus (MSSA) and 70% of methicillin-susceptible Staphylococcus epidermidis (MSSE) and Corynebacterium strains were resistant to fluoroquinolones. Methicillin-resistant Staphylococcus epidermidis (MRSE) demonstrated stable susceptibility to vancomycin, teicoplanin, and linezolid. Enterococcus faecalis remained susceptible to ampicillin (94.4%), vancomycin, linezolid, and tigecycline (100%). Multidrug-resistant strains predominated among nonfermenting Gram-negative bacteria and Klebsiella pneumoniae, whereas extended-spectrum β-lactamase producers were most common among Enterobacteriaceae. In 2024, pandrug–resistant Gram-negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) resistant to vancomycin were identified for the first time. Multidrug resistance was mainly observed in Gram-negative bacteria, particularly among nonfermenters such as Acinetobacter baumannii and Pseudomonas aeruginosa. Gram-positive pathogens, especially MSSE, remained highly susceptible to the tested antibiotics. CONCLUSION: Combination therapy with vancomycin and meropenem remains effective due to the high susceptibility of Gram-positive bacteria to vancomycin and Enterobacter…
creator: Archil V. Tsiskarashvili
creator: Regina E. Melikova
creator: Anton G. Nazarenko
creator: Vitaly A. Otdelenov
creator: Natalia K. Vabishchevich
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 799
ending page: 816
doi: 10.17816/vto683059

Modeling a clinical instrumental system for objective assessment of foot function in patients with post-traumatic deformity of the ankle and calcaneus
type: item
description: BACKGROUND: Gait alterations in patients after surgery on the ankle and foot are associated with biomechanically driven complications. The surgery outcomes depend on an accurate assessment of the anatomical and functional characteristics of the foot. Clinical gait analysis was performed using the computerized hardware-software system F-Scan Mobile. AIM: This study aimed to evaluate biomechanical gait parameters in patients with deformities of the ankle and foot before and after surgery. METHODS: A single-center, prospective, non-randomized, controlled, experimental, quantitative, cohort study was conducted at the Department of Traumatology and Orthopedics No. 4 of the Priorov National Medical Research Center of Traumatology and Orthopedics (Moscow) during 2022–2024. A total of 102 patients with ankle arthrosis and post-traumatic calcaneal deformity were treated, including 68 men and 34 women, a mean age of 39 ± 17.61 years. All patients also underwent biomechanical assessment of functional foot parameters. RESULTS: Treatment outcomes in patients included in the study were assessed 12 and 24 months after surgery. The mean follow-up period was 22.3 ± 9.42 months. The mean visual analog scale score before surgery was 6.5 ± 3.63, and 1.6 ± 0.81 after surgery, indicating a significant reduction in pain (p < 0.05). The mean AOFAS hindfoot score increased from 38 ± 23.31 preoperatively to 88 ± 10.55 postoperatively, with a significant improvement in questionnaire scores (p < 0.05). Subjective evaluation of treatment outcomes: 56 patients (54.9%) rated the results as excellent, 30 (29.4%) as good, 14 (13.7%) as satisfactory, and 2 (1.9%) as unsatisfactory. CONCLUSION: The clinical model for biomechanical gait assessment provides objective data on the structure of the gait cycle in unilateral foot lesions and allows evaluating the adequacy of adaptive motor skills in patients before and after surgery, as well as during long-term follow-up. Patients were satisfied with the tr…
creator: Аnatoliy K. Orletskiy
creator: Igor S. Kosov
creator: Konstantin V. Shkuro
creator: Dmitriy O. Timchenko
creator: Dmitriy O. Vasilyev
creator: Nicolay A. Gordeev
creator: Vladislav A. Jarikov
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 817
ending page: 829
doi: 10.17816/vto642295

Evaluation of the wear rate of the acetabular component in total hip arthroplasty using russian ultra-high-molecular-weight polyethylene
type: item
description: BACKGROUND: Russian ultra-high-molecular-weight polyethylene has previously demonstrated, in tribological pin-on-disk tests, a coefficient of friction comparable to commercial ultra-high-molecular-weight polyethylene grades Gur1020 and Gur1050 (Chirulen). From a clinical perspective, wear values of prosthetic components obtained under conditions simulating in vivo performance in accordance with GOST R ISO 14242-1—including kinematics, loading, and lubrication—are critical in the selection of orthopedic implants. AIM: This study aimed to investigate the wear rate of experimental ultra-high-molecular-weight polyethylene liners in the hip joint bearing pair of a total hip prostheses according to GOST R ISO 14242 (Parts 1 and 2). METHODS: It was a pilot single-center study; the object was the hip joint bearing pair with a total sample of four specimens. The study was experimental, with both quantitative and qualitative data obtained and monitored at 0.5, 1, 2, 3, 4, and 5 million cycles. The study control was both descriptive and quantitative, accounting for before–after values. Wear testing of hip prosthesis bearing pairs, one component of which was ultra-high-molecular-weight polyethylene manufactured by Engineering Polymers (Russia), was carried out in accordance with GOST R ISO 14242 (Parts 1 and 2) using a hip prosthesis wear simulator (Center for Technical Safety of Materials, Equipment, and Complex Systems, ElectronTest Group, Russia), which enabled evaluation of the wear resistance of the bearing pair. Wear mechanisms were analyzed using scanning electron microscopy, roughness assessment, and deviation from sphericity of the hip joint bearing components. RESULTS: Baseline deviations from sphericity and surface roughness of the bearing components complied with GOST R ISO 7206-2. After 5 million cycles according to GOST R ISO 14242-2, the mean wear rate across three test pairs was 19.8 ± 2.1 mg/ million cycles, which, according to published data, is lower or compa…
creator: Yulia S. Lukina
creator: Sergey M. Mihalkin
creator: Aleksandr S. Zabolotnov
creator: Vladimir I. Zubtsov
creator: Mihail M. Smorchkov
creator: Nikolay V. Zagorodniy
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 830
ending page: 842
doi: 10.17816/vto687389

Genetic risk factors for musculoskeletal injuries and disorders in athletes of the national teams of the Russian Federation
type: item
description: BACKGROUND: A high incidence of musculoskeletal injuries and disorders is a major challenge in elite sports. Although the contribution of genetic factors to individual risk is well recognized, the spectrum and frequency of associated genetic variants in a key population—athletes representing national teams of the Russian Federation—remain insufficiently studied, which limits the development of personalized preventive approaches. This work aimed to fill this knowledge gap. AIM: The work aimed to determine the frequency and distribution of gene variants associated with the risk of musculoskeletal injuries and disorders among athletes of the Russian national teams. METHODS: A cross-sectional retrospective study was conducted in athletes of national teams of the Russian Federation aged 18–40 years who provided written informed consent and underwent comprehensive medical examination (CME) in accordance with established procedures. The exclusion criterion was the absence of signed informed consent or incomplete CME data. Study groups were formed based on CME findings: the case group included athletes with a history of at least one musculoskeletal injury or disorder, whereas the control group comprised athletes without any documented musculoskeletal condition. The study was performed at the National Center for Sports Medicine (NCSM) and the Center of Sports Preparation (CSP), both under the Federal Medical-Biological Agency of Russia. Participants were enrolled, and retrospective data were collected from electronic CME databases between 2021 and 2024. RESULTS: Among 152 athletes, 94 (61.8%) had a history of musculoskeletal injuries or disorders. Several genetic associations with outcome were identified for a number of variants. The highest odds ratios (ORs) were observed for the A allele of the IL18RAP gene (rs1420100, OR 31.81; p = 0.003) and the C allele of the FGF10 gene (rs1448037, OR 57.16; p = 0.003). Protective effects were shown for the G allele of the MIR608 gene …
creator: Andrey V. Zholinsky
creator: Anastasia I. Kadykova
creator: Nikita S. Gladyshev
creator: Evgeny D. Kopylov
creator: Aleksandra A. Mamchur
creator: Mikhail V. Terekhov
creator: Aleksey A. Ivashechkin
creator: Mikhail V. Ivanov
creator: Daria A. Kashtanova
creator: Vladimir S. Yudin
creator: Anton A. Keskinov
creator: Sergey M. Yudin
creator: Veronika I. Skvortsova
creator: Roman V. Deev
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-11-01
publication date: 2025-11-01
volume: 32
number: 4
starting page: 843
ending page: 858
doi: 10.17816/vto693687

Diagnosing low-grade central osteosarcoma using a neural network mathematical model: a case report and review
type: item
description: BACKGROUND: Diagnosing low-grade central osteosarcoma is associated with a significant challenge because, according to radiological and histological findings, the condition closely resembles various benign lesions, most commonly being misdiagnosed as fibrous dysplasia. Convolutional neural network-based mathematical models have been successfully applied for the automated analysis of digital histopathological images, including tumor classification, regions of interest segmentation, and identification of morphological features of malignancy. CASE DESCRIPTION: This paper presents a clinical case of a 33-year-old female patient in whom, following a pathologic fracture of the femoral diaphysis, the lesion was long misinterpreted as fibrous dysplasia. Upon re-evaluation of histological slides and repeat biopsy at the N.N. Priorov National Medical Research Center of Traumatology and Orthopedics, the diagnosis of low-grade central osteosarcoma with areas of dedifferentiation and formation of high-grade osteosarcoma foci was established. For additional diagnostic confirmation, a convolutional neural network (ResNet-101)-based mathematical model previously developed by the authors for automated detection of pathologic mitoses on digital histopathological images was applied. The model analyzed scanned slides (Leica Aperio CS2, ×400), identifying several structures with a high probability of pathologic mitoses (maximum confidence scores: 99% and 92%), consistent with the conclusions of two experienced pathologists, thereby confirming the malignant nature of the lesion. CONCLUSION: This paper presents a clinicopathological and radiologic description of the condition, discusses diagnostic challenges and similarities with fibrous dysplasia and other benign lesions, and evaluates the potential and limitations of artificial intelligence techniques in pathology for rare low-mitotic tumors. Emphasis is placed on the role of neural network analysis as an auxiliary tool for improving re…
creator: Gennadiy N. Berchenko
creator: Alexander K. Morozov
creator: Vadim Y. Karpenko
creator: Olga B. Shugaeva
creator: Alexander F. Kolondaev
creator: Nina V. Fedosova
rights: Copyright (c) 2025 Eco-Vector https://creativecommons.org/licenses/by-nc-nd/4.0/
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
date: 2025-11-04
publication date: 2025-11-04
volume: 32
number: 4
starting page: 859
ending page: 870
doi: 10.17816/vto692675

Radiofrequency echographic multispectrometry: a promising method for the diagnosis of osteoporosis and the assessment of low-energy fracture risk
type: item
description: Osteoporosis is a metabolic skeletal disease characterized by reduced bone mass, impaired microarchitecture, and an increased risk of fractures. Low-energy fractures resulting from osteoporosis lead to severe complications and patient mortality, diminish quality of life, and represent a serious medical, social, and economic burden for society. Timely diagnosis of the disease and prediction of fracture risk remain largely unresolved issues, requiring the development and implementation of new technologies. Radiofrequency echographic multispectrometry is an innovative ultrasound-based technique for diagnosing osteoporosis and assessing fracture risk. Its main advantage over other ultrasound densitometry methods is the assessment of bone status not in peripheral skeletal sites, but in the principal regions used for diagnosing the disease—the lumbar vertebrae and the proximal femur. Unlike dual-energy X-ray absorptiometry, considered the gold standard, radiofrequency echographic multispectrometry does not measure bone mineral density but instead assesses integral parameters of bone status by comparing the spectra of ultrasound signals reflected from the bone surface in patients with osteoporosis, healthy individuals, and individuals with a history of low-energy fractures. An important advantage of radiofrequency echographic multispectrometry is the portability of its equipment, which increases accessibility in remote regions and for less mobile patient groups. International studies have demonstrated a high level of concordance between radiofrequency echographic multispectrometry and dual-energy X-ray absorptiometry findings, providing the basis for recommending this new technique for clinical use in patients with osteoporosis in several countries. At the same time, the different underlying principle of the method offers potential benefits that still require further validation. This article reviews the potential applications and unresolved issues of radiofrequency echogra…
creator: Aleksandr F. Kolondaev
creator: Valentina V. Makogon
creator: Marina A. Dobritsyna
creator: Nikolay A. Eskin
creator: Svetlana S. Rodionova
rights: Copyright (c) 2025 Eco-Vector https://eco-vector.com/for_authors.php#07
date: 2025-10-10
publication date: 2025-10-10
volume: 32
number: 4
starting page: 871
ending page: 882
doi: 10.17816/vto679951