Parameters of the CD4-Cell count and viral load in human immunodeficiency virus type 1 (HIV-1) infected patients
- 作者: Selimova L.М.1,2, Serebrovskaya L.V.1,2, Ivanova L.А.2, Kravchenko А.V.2, Buravtsova Е.V.2
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隶属关系:
- “The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation
- Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
- 期: 卷 60, 编号 2 (2015)
- 页面: 31-34
- 栏目: ORIGINAL RESEARCH
- URL: https://ogarev-online.ru/0507-4088/article/view/118073
- ID: 118073
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详细
In this work the specific features of parameters of plasma CD4 T-lymphocytes count and level virus RNA in the HIV-infected patients were studied. 22% correlation between reduction of CD4 cell count and an increase in virus RNA level was observed in persons that did not receive antiretroviral treatment during the third HIV- infection phase. During this phase of infection patients exhibited a growth of the median value of virus load in cases of both rise as decline in CD4 cell count during long observation period. In addition, towards the end of the observation period, the percentage of patients with virus load >3.3 lg copies/ml considerably expanded. 43% correlation between CD4 cell count and duration of the HIV-infection was detected during the fourth infection phase in persons that did not receive antiretroviral treatment. Most of the patients in the third and the fourth infection phases had essential CD4 cell count growth during antiretroviral treatment. Best values were observed in patients with the initial value of CD4 >400 cells/pl belonging to the third HIV-infection phase.
作者简介
L. Selimova
“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation; Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
编辑信件的主要联系方式.
Email: lselim@mail.ru
Lyudmila Selimova, Doctor of Biological Sciences
123098, Moscow
105275, Moscow
俄罗斯联邦L. Serebrovskaya
“The D.I. Ivanovsky Institute of Virology” Federal State Budgetary Institution “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation; Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
123098, Moscow
105275, Moscow
俄罗斯联邦L. Ivanova
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow 俄罗斯联邦
А. Kravchenko
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow 俄罗斯联邦
Е. Buravtsova
Central Research Institute of Epidemiology, Federal Supervision Service for the of Consumer Rights Protection and People’s Welfare
Email: fake@neicon.ru
105275, Moscow 俄罗斯联邦
参考
- Mellors J.W., Margolick J.B., Phair J.P., Rinaldo C.R., Detels R., Jacobson L.P. et al. Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection. J. A. M. A. 2007; 297 (21): 2349–50.
- Покровский В.В., ред. ВИЧ-инфекция и СПИД: Клинические рекомендации. 2-е изд. М.: Медицина; 2009.
- Kaslow R.A., Dorak T., Tang J.J. Influence of host genetic variation on susceptibility to HIV type 1 infection. J. Infect. Dis. 2005; 191 Suppl 1: S68–77.
- Phillips A.N., Lampe F.C., Smith C.J., Geretti A.M., Rodger A., Lodwick R.K., Cambiano V. et al. Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion. AIDS. 2010; 24 (10): 1561–7.
- Zhou J., Sirisanthana T., Kiertiburanakul S., Chen Y.M., Han N., Lim P.L. et al. Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database. BMC Infect. Dis. 2010; 10: 361–70.
- Rodríguez B., Sethi A.K., Cheruvu V.K., Mackay W., Bosch R.J., Kitahata M. et al. Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection. J. A. M. A. 2006; 296 (12): 1498–506.
- Kaufmann G.R., Furrer H., Ledergerber B., Perrin L., Opravil M., Vernazza P. et al. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy. Clin. Infect. Dis. 2005; 41 (3): 361–72.
- Rockstroh J.K., Mocroft A., Soriano V., Tural C., Losso M.H., Horban A. et al. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J. Infect. Dis. 2005; 192 (6): 992–1002.
- Viard J.P., Mocroft A., Chiesi A., Kirk O., Røge B., Panos G. et.al. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J. Infect. Dis. 2001; 183 (8): 1290–4.
- Шмагель Н.Г., Шмагель К.В., Черешнев В.А. Клинические аспекты иммунологической неэффективности высокоактивной антиретровирусной терапии. Инфекционные болезни. 2011; 9 (1): 5–10.
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