Avian recombinant virus H5N1 influenza (A/Vietnam/1203/04) and its escape-mutant m13(13) induce early signaling reactions of the immunity in human lymphocytes
- 作者: Sokolova T.M.1, Poloskov V.V.1, Shuvalov A.N.1, Rudneva I.A.1, Ershov F.I.1
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隶属关系:
- D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
- 期: 卷 61, 编号 1 (2016)
- 页面: 21-26
- 栏目: ORIGINAL RESEARCH
- URL: https://ogarev-online.ru/0507-4088/article/view/118035
- DOI: https://doi.org/10.18821/0507-4088-2016-61-1-21-26
- ID: 118035
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详细
The innate immune receptors TLR4, TLR7, TLR8, and RIG1 recognized the structures of the influenza viruses in human lymphocytes and were activated by the recombinant avian influenza virus A/Vietnam/1203/04 and its escape-mutant m13(13) during early period of interaction. The stimulated levels are not connected with viral reproduction. Donor cells with the low constitutive immune receptors gene expression levels showed higher stimulation. Inflammation virus effects resulted in increasing production of TNF-alpha and IFN-gamma by lymphocytes. Signaling gene reactions of the parent and mutant viruses endosomal as well as cytoplasmic receptors are very similar. The mutant virus A/Vietnam/1203/04 (HA S145F) stimulated an increase in the transcription level of the membrane receptor gene TLR4 and a decrease in the level of activation of TNF-alpha gene. Further studies of natural influenza virus isolates are necessary to estimate the role of HA antigenic changes on immune reactions in humans.
作者简介
T. Sokolova
D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
编辑信件的主要联系方式.
Email: tmsokolovavir@mail.ru
Tatyana Sokolova, Doctor of Biological Sciences, Academician of the Russian Academy of natura Sciences
123098, Moscow
俄罗斯联邦V. Poloskov
D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
Email: fake@neicon.ru
123098, Moscow 俄罗斯联邦
A. Shuvalov
D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
Email: fake@neicon.ru
123098, Moscow 俄罗斯联邦
I. Rudneva
D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
Email: fake@neicon.ru
123098, Moscow 俄罗斯联邦
F. Ershov
D.I. Ivanovsky Institute of Virology “Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya”
Email: fake@neicon.ru
123098, Moscow 俄罗斯联邦
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