Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011)
- 作者: Lebedev A.V.1,2, Kazennova E.V.1, Zverev S.Y.3, Nistratova Y.I.3, Laga V.Y.1, Tumanov A.S.1, Glushchenko N.V.1, Yarygina E.I.2, Bobkova M.R.1
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隶属关系:
- «Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
- K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- Perm Regional Center for Prevention and Control of AIDS and Infectious Diseases
- 期: 卷 61, 编号 5 (2016)
- 页面: 222-229
- 栏目: ORIGINAL RESEARCH
- URL: https://ogarev-online.ru/0507-4088/article/view/117895
- DOI: https://doi.org/10.18821/0507-4088-2016-61-5-222-229
- ID: 117895
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In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of the IDU-A HIV-1 viruses from a common ancestor increased 4.3 times (p < 0.001) in 2011 as compared with the onset of the epidemics. The rate of the HIV-1 evolution was different in the two risk groups of the infection. The mean genetic distance of HIV-1 variants circulating among heterosexuals was 1.3 times longer (p = 0.008) than that among IDUs. The accumulation rate of the nucleotide (including nonsynonymous) substitutions in the C2-V3-C3 HIV-1 env gene region among individuals infected by heterosexual contacts was 1.7 times higher than that among IDUs. The differences in the positions of the codons subjected to positive selection were demonstrated depending on the infection risk group tested.
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作者简介
A. Lebedev
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»; K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
编辑信件的主要联系方式.
Email: lebedevalesha236@gmail.com
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E. Kazennova
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
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S. Zverev
Perm Regional Center for Prevention and Control of AIDS and Infectious Diseases
Email: noemail@neicon.ru
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Yu. Nistratova
Perm Regional Center for Prevention and Control of AIDS and Infectious Diseases
Email: noemail@neicon.ru
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V. Laga
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
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A. Tumanov
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
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N. Glushchenko
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
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E. Yarygina
K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: noemail@neicon.ru
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M. Bobkova
«Federal Research Centre of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
俄罗斯联邦
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