The role of the components of the immune system in preterm birth due to placental dysfunction
- 作者: Nikolaeva A.S.1, Tanysheva G.A.1, Koliado O.V.2, Remneva O.V.2, Molchanova I.V.2, Dyusupov A.A.1
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隶属关系:
- Semey Medical University
- Altai State Medical University, Ministry of Health of Russia
- 期: 编号 4 (2025)
- 页面: 79-84
- 栏目: Original Articles
- URL: https://ogarev-online.ru/0300-9092/article/view/309921
- DOI: https://doi.org/10.18565/aig.2025.28
- ID: 309921
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Objective: To evaluate the role of the components of the immune system in the pathogenesis of preterm birth due to severe preeclampsia and placental abruption of normally implanted placenta.
Materials and methods: A total of 80 women with induced preterm birth (the main group) were examined. The sample was divided into two subgroups. Subgroup 1 consisted of patients with abdominal delivery due to progression of severe preeclampsia. Subgroup 2 consisted of patients with preterm birth due to placental abruption of normally implanted placenta. The control group consisted of women with term uncomplicated birth. The levels of interleukin (IL)-8, IL-10, tumor necrosis factor alpha (TNF-α), human chorionic gonadotropin and pregnancy-associated plasma protein A (PAPP-A) were studied as the predictors of preterm birth.
Results: It was found that IL-8, TNF-α and PAPP-A play an important role in the pathogenesis of induced preterm birth due to severe obstetric complications. Elevation of IL-8 level by 1 unit increases the risk of preterm birth by 2.96 times; elevation of TNF-α level by 1 unit increases the risk of preterm birth by 1.56 times, while elevation of PAPP-A level by 1 unit reduces the risk of adverse outcomes by 0.04 times.
Conclusion: The components of the immune system play an important role in the pathogenesis of preterm birth and placental dysfunction. Research in this area expands knowledge of the mechanisms of severe obstetric complications and is important for prediction of adverse obstetric outcomes.
作者简介
Anna Nikolaeva
Semey Medical University
Email: avealokinanna@mail.ru
ORCID iD: 0000-0002-2642-5141
Researcher at the A.A. Kozbagarov Department of Obstetrics and Gynecology
哈萨克斯坦, 071400, Semey, Abay str., 103Gulyash Tanysheva
Semey Medical University
Email: gulyash1965@mail.ru
ORCID iD: 0000-0001-9531-5950
PhD, Associate Professor, Head of the A.A. Kozbagarov Department of Obstetrics and Gynecology
哈萨克斯坦, 071400, Semey, Abay str., 103Olga Koliado
Altai State Medical University, Ministry of Health of Russia
Email: olga.kolyado@yandex.ru
ORCID iD: 0000-0002-5812-4925
PhD, Teaching Assistant at the Department of Obstetrics, Gynecology with course of additional professional education
俄罗斯联邦, 656038, Barnaul, Lenin str., 40Olga Remneva
Altai State Medical University, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: rolmed@yandex.ru
ORCID iD: 0000-0002-5984-1109
Dr. Med. Sci., Professor, Head of the Department of Obstetrics, Gynecology with course of additional professional education
俄罗斯联邦, 656038, Barnaul, Lenin str., 40Irina Molchanova
Altai State Medical University, Ministry of Health of Russia
Email: molcanova2008@yandex.ru
ORCID iD: 0000-0002-0741-8974
PhD, Associate Professor at the Department of Obstetrics, Gynecology with course of additional professional education
俄罗斯联邦, 656038, Barnaul, Lenin str., 40Altay Dyusupov
Semey Medical University
Email: altay.dyusupov@smu.edu.kz
ORCID iD: 0000-0003-0875-1020
Dr. Med. Sci., Professor, Rector
哈萨克斯坦, 071400, Semey, Abay str., 103参考
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