Water-Soluble Anionic C60-Fullerene Derivatives as Antidotes for HG(II) Ions in Tests on Escherichia Coli Cells
- 作者: Zhilenkov A.V.1, Khakina E.A.1, Troshin P.A.1,2, Karimov I.F.3,4, Deryabin D.G.3
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隶属关系:
- Institute for Problems of Chemical Physics, Russian Academy of Sciences
- Skolkovo Institute of Science and Technology
- Federal Scientific Center of Biological Systems and Agrotechnologies
- Orenburg State University
- 期: 卷 53, 编号 4 (2019)
- 页面: 312-317
- 栏目: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/245747
- DOI: https://doi.org/10.1007/s11094-019-01998-x
- ID: 245747
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详细
Three water-soluble C60-fullerene derivatives functionalized by anionic adducts of various chemical compositions and structures were prepared in highly specific reactions of chlorofullerene C60Cl6. Hybrid metal-organic complexes formed and aggregated in several instances in aqueous solution in the presence of stoichiometric (1:1 by moles) amounts of synthesized C60-fullerene derivatives and Hg(II) ions. The bioavailability of Hg(II) ions for Escherichia coli cells was reduced by such a reaction and manifested as decreased toxicity for strain E. coli K12 TG1 pF1 or weakened protective reactions of strain E. coli K12 MG1655 pMerA'::lux. The most pronounced protective effect was recorded for the C60-fullerene derivative functionalized by S-containing adducts of general formula –S(CH2)10CO2K with antidote activity comparable with that of the pharmacopoeial preparation Unithiol.
作者简介
A. Zhilenkov
Institute for Problems of Chemical Physics, Russian Academy of Sciences
Email: troshin2003@inbox.ru
俄罗斯联邦, 1 Prosp. Akademika Semenova, Chernogolovka, Moscow, Oblast, 142432
E. Khakina
Institute for Problems of Chemical Physics, Russian Academy of Sciences
Email: troshin2003@inbox.ru
俄罗斯联邦, 1 Prosp. Akademika Semenova, Chernogolovka, Moscow, Oblast, 142432
P. Troshin
Institute for Problems of Chemical Physics, Russian Academy of Sciences; Skolkovo Institute of Science and Technology
编辑信件的主要联系方式.
Email: troshin2003@inbox.ru
俄罗斯联邦, 1 Prosp. Akademika Semenova, Chernogolovka, Moscow, Oblast, 142432; 3 Nobel St., Orenburg, 143026
I. Karimov
Federal Scientific Center of Biological Systems and Agrotechnologies; Orenburg State University
Email: troshin2003@inbox.ru
俄罗斯联邦, 29 9th of January St., Orenburg, 460000; 13 Prosp. Pobedy, Orenburg, 460018
D. Deryabin
Federal Scientific Center of Biological Systems and Agrotechnologies
Email: troshin2003@inbox.ru
俄罗斯联邦, 29 9th of January St., Orenburg, 460000
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