Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin


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Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.

作者简介

I. Krasnyuk

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

T. Kosheleva

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

A. Belyatskaya

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

I. Krasnyuk

I. M. Sechenov First Moscow State Medical University

编辑信件的主要联系方式.
Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

O. Stepanova

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

Yu. Skovpen

Rancho BioSciences

Email: krasnyuk.79@mail.ru
美国, 16955 Via Del Campo Suite 220, San Diego, CA, 92127

V. Grikh

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

L. Ovsyannikova

I. M. Sechenov First Moscow State Medical University

Email: krasnyuk.79@mail.ru
俄罗斯联邦, 8/2 Trubetskaya St., Moscow, 119991

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