Glucokinase Activators Based on  N -Aryl- N ′-Pyridin-2-Ylurea Derivatives

A. V. Semenov; I. V. Tarasova; V. S. Khramov; E. V. Semenova; V. I. Inchina; S. S. Vakaeva

doi:10.1007/s11094-018-1792-7

Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives

作者: Semenov A.V.¹, Tarasova I.V.¹, Khramov V.S.¹, Semenova E.V.¹, Inchina V.I.¹, Vakaeva S.S.¹
隶属关系:
1. N. P. Ogarev National Research Mordovia State University
期: 卷 52, 编号 3 (2018)
页面: 209-212
栏目: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245080
DOI: https://doi.org/10.1007/s11094-018-1792-7
ID: 245080

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详细

A series of previously undescribed N-aryl-N′-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.