Encapsulation and Controlled Release of Vitamin B2 Using Peracetyl-β-Cyclodextrin Polymer-Based Electrospun Nanofiber Scaffold


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Hydrophobic β-cyclodextrin polymer nanofibers were obtained by the electrospinning of peracetyl-β-cyclodextrin polymer (AcβCDP) from acetone : DMF (3 : 2 v/v) solution. The morphology of AcβCDP nanofibers was studied by scanning electron microscopy. The proposed novel hydrophobic β-CD polymer was synthesized through reaction of water-soluble β-CD polymer crosslinked with epichlorohydrin (β-CD-ECH polymer) and acetic anhydride in the presence of pyridine. The peracylation of β-CD-ECH polymer is verified by FT-IR and solubility data. The final part of this study is focused on incorporating vitamin B2 (VB2) into the AcβCDP nanofiber. In vitro release of VB2 from AcβCDP/VB2 nanofiber in model physiological media was investigated; the results exhibited initial burst and then slow drug release. The release of VB2 from AcβCDP/VB2 nanofiber is slower than from AcβCDP/VB2.

作者简介

Abolfazl Heydari

Young Researchers and Elite Club, Kerman Branch, Islamic Azad University

Email: shamspur@gmail.com
伊朗伊斯兰共和国, Kerman, 76169

Fatemeh Mehrabi

Department of Chemistry, Shahid Bahonar University of Kerman

Email: shamspur@gmail.com
伊朗伊斯兰共和国, Kerman, 76169

Tayebeh Shamspur

Department of Chemistry, Shahid Bahonar University of Kerman

编辑信件的主要联系方式.
Email: shamspur@gmail.com
伊朗伊斯兰共和国, Kerman, 76169

Hassan Sheibani

Department of Chemistry, Shahid Bahonar University of Kerman

Email: shamspur@gmail.com
伊朗伊斯兰共和国, Kerman, 76169

Ali Mostafavi

Department of Chemistry, Shahid Bahonar University of Kerman

Email: shamspur@gmail.com
伊朗伊斯兰共和国, Kerman, 76169

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