电邮这篇文章 Synthesis of and HIV-1 Integrase Inhibition by 2-[7-(Fluorobenzyloxy)-4-Oxo-4hchromen-3-Yl]-1-Hydroxyimidazoles
- 作者: Nikitina P.A.1, Tkach I.I.1, Knyazhanskaya E.S.2, Gottikh M.B.2, Perevalov V.P.1
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隶属关系:
- D. I. Mendeleev University of Chemical Technology of Russia
- Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
- 期: 卷 50, 编号 8 (2016)
- 页面: 513-518
- 栏目: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244426
- DOI: https://doi.org/10.1007/s11094-016-1479-x
- ID: 244426
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详细
A series of six new 2-[7-(fluorobenzyloxy)-4-oxo-4H-chromen-3-yl]-1-hydroxyimidazoles were synthesized and characterized as potential HIV-1 integrase inhibitors. Prototropic tautomerism of the obtained 1-hydroxyimidazoles was discussed. Their ability to inhibit integrase catalytic activity in 3′-terminal processing and chain transfer reactions was studied. It was shown that these compounds did not exhibit noticeable inhibition.
作者简介
P. Nikitina
D. I. Mendeleev University of Chemical Technology of Russia
编辑信件的主要联系方式.
Email: polinandrevna@yandex.ru
俄罗斯联邦, 9 Miusskaya Sq, Moscow, 125047
I. Tkach
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
俄罗斯联邦, 9 Miusskaya Sq, Moscow, 125047
E. Knyazhanskaya
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
俄罗斯联邦, Moscow, 119991
M. Gottikh
Department of Chemistry and A. N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University
Email: polinandrevna@yandex.ru
俄罗斯联邦, Moscow, 119991
V. Perevalov
D. I. Mendeleev University of Chemical Technology of Russia
Email: polinandrevna@yandex.ru
俄罗斯联邦, 9 Miusskaya Sq, Moscow, 125047
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