Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A

Resumo

Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution. Moreover, the hydroxy substitution did not increase the cytotoxicity of glaucocalyxin A significantly. Other glaucocalyxin A derivatives should be obtained by skeleton modification to find compounds with significant cytotoxicity for research and development of new antitumor drugs.