Synthesis and Cardiotropic Activity of Linear Methoxyphenyltriazaalkanes
- Авторы: Mokrov G.V.1, Likhosherstov A.M.1, Barchukov V.V.1, Stolyaruk V.N.1, Tsorin I.B.1, Vititnova M.B.1, Kryzhanovskii S.A.1, Gudasheva T.A.1, Seredenin S.B.1
-
Учреждения:
- V. V. Zakusov State Institute of Pharmacology
- Выпуск: Том 53, № 6 (2019)
- Страницы: 500-506
- Раздел: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245832
- DOI: https://doi.org/10.1007/s11094-019-02027-7
- ID: 245832
Цитировать
Аннотация
A new group of potential pFOX inhibitors among linear methoxyphenyltriazaalkanes were designed and synthesized. Cardiotropic activity in rodent experiments was found for most of the synthesized compounds. The most active compound N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine trihydrochloride (LM-1) combined anti-ischemic, antiarrhythmic, and antifibrillatory activities (1 mg/kg, i.v.) and low toxicity (LD50 = 119 mg/kg, mice, i.p.) and was selected for development as a potential cardiotropic drug.
Об авторах
G. Mokrov
V. V. Zakusov State Institute of Pharmacology
Автор, ответственный за переписку.
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
A. Likhosherstov
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
V. Barchukov
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
V. Stolyaruk
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
I. Tsorin
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
M. Vititnova
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
S. Kryzhanovskii
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
T. Gudasheva
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
S. Seredenin
V. V. Zakusov State Institute of Pharmacology
Email: g.mokrov@gmail.com
Россия, 8 Baltiiskaya St., Moscow, 125315
Дополнительные файлы
