Отправить статью по E-mail Practical Issues of Preclinical Pharmacokinetic Investigations of New Drugs (Review)
- Авторы: Chistyakov V.V.1, Stepanova E.S.1
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Учреждения:
- People’s Friendship University of Russia, Common Use Center
- Выпуск: Том 53, № 4 (2019)
- Страницы: 281-287
- Раздел: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://ogarev-online.ru/0091-150X/article/view/245740
- DOI: https://doi.org/10.1007/s11094-019-01995-0
- ID: 245740
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Аннотация
Several issues with pharmacokinetic studies of new drugs, in particular, experiment planning, development of study protocols, dose selection, and administration routes, are reviewed. The number of used animals is justified statistically with respect to bioethics. The pharmacokinetic study protocol is discussed in more detail according to domestic regulatory requirements. Modern approaches to combining bioanalytical methods with pharmacokinetic studies are described.
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Об авторах
V. Chistyakov
People’s Friendship University of Russia, Common Use Center
Email: stepanova_25@inbox.ru
Россия, Moscow, 117198
E. Stepanova
People’s Friendship University of Russia, Common Use Center
Автор, ответственный за переписку.
Email: stepanova_25@inbox.ru
Россия, Moscow, 117198
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