Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1 H -Purine-2,6(3 H ,7 H )-Dione

F. A. Khaliullin; Yu. V. Shabalina; G. G. Davlyatova; L. A. Valeeva

doi:10.1007/s11094-018-1738-0

Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione

作者: Khaliullin F.A.¹, Shabalina Y.V.¹, Davlyatova G.G.¹, Valeeva L.A.¹
隶属关系:
1. Bashkir State Medical University, Ministry of Health of the RF, Ufa
期: 卷 51, 编号 12 (2018)
页面: 1049-1052
栏目: Search for New Drugs
URL: https://ogarev-online.ru/0091-150X/article/view/244908
DOI: https://doi.org/10.1007/s11094-018-1738-0
ID: 244908

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3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.