Enviar artigo por via de e-mail Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4
- Autores: Shirinyan V.Z.1, Markosyan A.I.2, Baryshnikova M.A.3, Yaminova L.V.4, L’vov A.G.1, Gabrielyan S.A.2
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Afiliações:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Edição: Volume 51, Nº 10 (2018)
- Páginas: 867-872
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244834
- DOI: https://doi.org/10.1007/s11094-018-1706-8
- ID: 244834
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Resumo
A series of previously unreported di- and triaryl(hetaryl)cyclopentenone derivatives were prepared using a convenient synthetic method and screened preliminarily for antitumor activity in four human cell lines, i.e., T-cell leukemia (Jurkat), lung adenocarcinoma (A-549), colon cancer (HCT-116), and breast adenocarcinoma (MCF-7). The most cytotoxic of the tested compounds was 2-(3,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl) cyclopent-2-en-1-one. However, it was inactive against lymphocytic leukemia P388 in mice despite its cytotoxicity in in vitro tests.
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Sobre autores
V. Shirinyan
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: shir@ioc.ac.ru
Rússia, 47 Leninskii Prosp, Moscow, 119991
A. Markosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Armênia, 26 Azatutyan Pr., 0014, Yerevan, 375014
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Email: shir@ioc.ac.ru
Rússia, 23 Kashirskoe Shosse, Moscow, 115478
L. Yaminova
D. I. Mendeleev University of Chemical Technology of Russia
Email: shir@ioc.ac.ru
Rússia, 9 Miusskaya Pl., Moscow, 125047
A. L’vov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: shir@ioc.ac.ru
Rússia, 47 Leninskii Prosp, Moscow, 119991
S. Gabrielyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Armênia, 26 Azatutyan Pr., 0014, Yerevan, 375014
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