Immunomodulating Activity of Extract of Gentiana Algida Pall.
- Авторы: Khobrakova V.B.1,2, Budaeva E.R.1, Olennikov D.N.1, Zilfikarov I.N.3
-
Учреждения:
- Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences
- Buryat State University
- Scientific Center of Biomedical Technologies, State Research Institute of Medicinal and Aromatic Plants (VILAR)
- Выпуск: Том 51, № 5 (2017)
- Страницы: 384-387
- Раздел: Medicinal Plants
- URL: https://ogarev-online.ru/0091-150X/article/view/244618
- DOI: https://doi.org/10.1007/s11094-017-1618-z
- ID: 244618
Цитировать
Аннотация
Dry extract of Gentiana algida Pall. displayed immunomodulating activity in experiments on mouse line F1 (CBA × C57B1/6) with experimental azathioprine-induced immunosuppression of the cellular, humoral, and macrophage components of the immune response. It was found that the plant extract reduced the suppressive effect of the cytostatic azathioprine on the antibody response, cell-mediated immune reaction, and macrophage phagocytosis. This resulted in increases as compared with the suppressed levels of the absolute and relative amounts of antibody-forming cells, index of delayed-type hypersensitivity, phagocytic index, and phagocyte number. Dry extract of G. algida was characterized chemically by high contents of iridoids (82.07 mg/g), flavonoids (86.91 mg/g), and triterpenes (23.98 mg/g), which caused the observed immunomodulating activity.
Ключевые слова
Об авторах
V. Khobrakova
Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences; Buryat State University
Автор, ответственный за переписку.
Email: evd_bud2688@mail.ru
Россия, Ulan-Ude, Buryat Republic, 670047; Ulan-Ude, Buryat Republic, 670000
E. Budaeva
Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences
Email: evd_bud2688@mail.ru
Россия, Ulan-Ude, Buryat Republic, 670047
D. Olennikov
Institute of General and Experimental Biology, Siberian Branch, Russian Academy of Sciences
Email: evd_bud2688@mail.ru
Россия, Ulan-Ude, Buryat Republic, 670047
I. Zilfikarov
Scientific Center of Biomedical Technologies, State Research Institute of Medicinal and Aromatic Plants (VILAR)
Email: evd_bud2688@mail.ru
Россия, Moscow, 117216
Дополнительные файлы
