Potential Synthetic Adaptogens. II. Synthesis and Pharmacological Activity of New Conformationally Labile Bromantane Analogs,  N -[(Adamantan-1-YL)Methyl]-4-Bromoanilines

A. S. Babushkin; M. B. Navrotskii; I. A. Novakov; B. S. Orlinson; M. D. Robinovich; D. S. Sheikin; S. N. Voloboev

doi:10.1007/s11094-017-1531-5

Potential Synthetic Adaptogens. II. Synthesis and Pharmacological Activity of New Conformationally Labile Bromantane Analogs, N-[(Adamantan-1-YL)Methyl]-4-Bromoanilines

Авторы: Babushkin A.S.¹, Navrotskii M.B.¹, Novakov I.A.¹, Orlinson B.S.¹, Robinovich M.D.¹, Sheikin D.S.¹, Voloboev S.N.²
Учреждения:
1. Volgograd State Technical University
2. Lukoil Volgograd Oil Refinery
Выпуск: Том 50, № 12 (2017)
Страницы: 781-787
Раздел: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244478
DOI: https://doi.org/10.1007/s11094-017-1531-5
ID: 244478

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Аннотация

New structural analogs of bromantane with greater conformational lability than the prototype were synthesized. Their physiological activity profiles were assessed in vivo. It was found that the analogs could be prepared under much milder conditions than bromantane and that their biological activity profiles dependedstrongly on the nature of adamantane substitution.